1539-44-2Relevant articles and documents
Aromatization of Hantzsch 1,4-dihydropyridines with I2-MeOH
Yadav,Subba Reddy,Sabitha,Kiran Kumar Reddy
, p. 1532 - 1534 (2000)
4-Alkyl or aryl substituted Hantzsch 1,4-dihydropyridines are aromatized to the corresponding pyridines in high yields by iodine in refluxing methanol. The method tolerates several substituents such as alkyl, benzyl, aryl and heterocyclic groups present i
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Kurbatova,Kurbatov
, (1979)
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Silica gel-supported bis(trimethylsilyl) chromate: Oxidation of 1,4-dihydropyridines to pyridines
Heravi, Majid M.,Derikvand, Fatemeh,Oskooie, Hossein A.,Shoar, Rahim Hekmat
, p. 77 - 82 (2006)
An efficient and convenient method for the oxidation of 1,4-dihydropyridines mediated by silica gel-supported bis(trimethylsilyl) chromate in refluxing CH2Cl2 is reported. Copyright Taylor & Francis LLC.
Ultrasound-Assisted Heterogeneous Oxidation of 1,4-Dihydropyridines
Abdoli-Senejani,Karami
, p. 274 - 281 (2020)
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N,N′-ethylene-bis(benzoylacetoniminato) copper (II), Cu(C 22H22N2O2), a new reagent for aromatization of Hantzsch 1,4-dihydropyridines
Dehghanpour, Saeed,Heravi, Majid M.,Derikvand, Fatemeh
, p. 433 - 438 (2007)
A variety of Hantzsch 1,4-dihydropyridines were oxidized to their corresponding pyridines in high yields in the presence of Cu(C 22H22N2O2) in refluxing acetic acid.
Aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines with HIO3 and I2O5 in water
Chai, Lingzhi,Zhao, Yankai,Sheng, Qiuju,Liu, Zhong-Quan
, p. 9283 - 9285 (2006)
Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines were converted to the corresponding pyridines and pyrazoles efficiently by the treatment of a catalytic amount of HIO3 or I2O5 in water.
Aromatization of hantzsch 1,4-dihydropyridines using barium manganate
Memarian,Sadeghi,Momeni
, p. 2241 - 2244 (2001)
Barium manganate has been used as an inexpensive and convenient reagent for efficient oxidation of a variety of 1,4-dihydropyridine derivatives to pyridine derivatives in refluxing benzene with excellent yields.
Oxidative Aromatization of 1,3,5-Trisubstituted Pyrazolines and Hantzsch 1,4-Dihydropyridines by Pd/C in Acetic Acid
Nakamichi, Natsuki,Kawashita, Yuka,Hayashi, Masahiko
, p. 3955 - 3957 (2002)
(Equation Presented) 1,3,5-Trisubstituted pyrazolines and Hantzsch 1,4-dihydropyridines were converted to the corresponding pyrazoles and pyridines effectively by the treatment of a catalytic amount of Pd/C in acetic acid.
Aromatization of 1,4-Dihydropyridines by Clay-Supported Metal Nitrates
Balogh, Maria,Hermecz, Istvan,Meszaros, Zoltan,Laszlo, Pierre
, p. 2270 - 2272 (1984)
1,4-Dihydropyridines can be aromatized under very mild conditions by K 10 clay-supported ferric and cupric nitrates.
Zeobis, a versatile reagent for the fast aromatization of Hantzsch 1,4-Dihydropyridines
Heravi, Majid M.,Bakhtiari, Khadijeh,Oskooie, Hossein A.,Hekmatshoa, Rahim
, p. 209 - 212 (2006)
Bismuth nitrate supported onto HZSM-5 zeolite (zeobis) has been found to be an efficient and selective reagent for the oxidation of Hantzsch 1,4-Dihydropyridines to the corresponding pyridine derivatives in excellent yields.
An efficient aerobic oxidative aromatization of Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines
Han, Bing,Liu, Zhengang,Liu, Qiang,Yang, Li,Liu, Zhong-Li,Yu, Wei
, p. 2492 - 2496 (2006)
4-Substituted Hantzsch 1,4-dihydropyridines and 1,3,5-trisubstituted pyrazolines were oxidized to the corresponding pyridines and pyrazoles, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N-hydroxyphthalimide (NHPI
Superparamagnetic core-shell metal–organic framework Fe3O4@Ni-MOF as efficient catalyst for oxidation of 1,4-dihydropyridines using hydrogen peroxide
Janani, Marzieh,Senejani, Masumeh Abdoli,Isfahani, Tahereh Momeni
, (2021/07/21)
A facile and efficient method was described for oxidation of some 3,5-diacyl or 3,5-diester 1,4-dihydropyridines using H2O2 in the presence of superparamagnetic core-shell metal–organic framework Fe3O4@Ni-MOF. The Fe3O4@Ni-MOF has been obtained by Step-by-Step method in which magnetic Fe3O4 magnetic nanoparticles were coated with Ni-MOF using a mercaptoacetic acid linker. The synthesized catalyst was characterized using thermogravimetric analysis, FT-IR spectroscopy, powder X-ray diffraction, field emission scanning electron microscopy and energy-dispersive X-ray analysis. The novel superparamagnetic core-shell metal–organic framework Fe3O4@Ni-MOF revealed high efficiency for oxidation of various 1,4-dihydropyridines using hydrogen peroxide. The Box–Behnken design matrix and the response surface method were applied to investigate the optimization of the reaction conditions. The conditions for optimal reaction yield and time were: amount of catalyst ≈17 mmol, temperature ≈78°C and amount of hydrogen peroxide ≈ 1 ml. A variety of 3,5-diacyl or 3,5-diester 1,4-dihydropyridines with different substituted functional groups have been converted to corresponding pyridines with good to excellent isolated yields using H2O2 and Fe3O4@Ni-MOF. The catalyst was reused up to five times for the oxidation of 1,4-dihydropyridines without a significant loss in catalytic activity. The short reaction times, simplicity of method, good to excellent yields and reusability of catalyst were some advantages of the proposed procedure.
Trinuclear cis-dioxidomolybdenum(VI) complexes of compartmental C3 symmetric ligands: Synthesis, characterization, DFT study and catalytic application for hydropyridines (Hps) via the Hantzsch reaction
Avecilla, Fernando,Gupta, Puneet,Maurya, Mannar R.,Tomar, Reshu
supporting information, (2020/06/08)
Trinuclear cis-dioxidomolybdenum(VI) complexes of the type [{MoVIO2(MeOH)}3L1-7] (1–7) have been synthesized using tris(H2ONO) donor ligands [H6L1-7 (I–VII)] assembled from benzene-1,3,5-tricarbohydrazide (bthz) and the corresponding salicylaldehyde (sal). All the ligands and the complexes were characterized by numerous techniques, such as FT-IR, UV–visible, NMR (1H and 13C) spectroscopy, electrochemical study, elemental analysis, thermogravimetric study and single crystal X-ray diffraction of the ligand III and complexes 1 and 5. In the presence of H2O2 as an oxidant, these complexes show excellent catalytic potential towards the one-pot three-components [ethyl acetoacetate, benzaldehyde (or its derivatives) and ammonium acetate] dynamic covalent assembly in the Hantzsch reaction. Under solvent free conditions, as high as 98% conversion along with 100% selectivity towards diethyl 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate (1,4-DHP) has been achieved in 1 h. Although solvents do not improve the conversion, they do influence the selectivity of the products. With the elapse of time, the conversion of dihydropyridine to the diethyl 2,6-dimethyl-4-phenylpyridine-3,5-dicarboxylate derivative occurs and completes in ca. 10 h with a distinct color change, showing the importance of the catalysts. Efforts have been made to provide suitable reaction pathways for the catalytic reaction based on spectroscopic and density functional theory studies.