1539320-94-9Relevant articles and documents
Formation of a Pseudo-β-hairpin motif utilizing the Ant-pro reverse turn: Consequences of stereochemical reordering
Nair, Roshna V.,Kotmale, Amol S.,Dhokale, Snehal A.,Gawade, Rupesh L.,Puranik, Vedavadi G.,Rajamohanan, Pattuparambil R.,Sanjayan, Gangadhar J.
, p. 774 - 782 (2014/01/23)
Herein, we report a special case of pseudo-β-hairpin formation by tetrapetide sequences featuring a two-membered Ant-Pro dipeptide motif (Ant = anthranilic acid and Pro = proline) at the loop region. These folded structures uniquely feature the presence of C9- and C17-H-bonding patterns at reverse turn and interstrand regions, respectively. Their hairpin nucleation and folding propensities have been expounded using solution and solid state studies of distinct stereochemically altered sequences.