154015-73-3

Basic information

• Product Name: 10-Fluoro-3-(2-fluorophenyl)-6,7-dihydro-5H-benz[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid
• Synonyms: KF-20444
• CAS NO: 154015-73-3
• Molecular Formula: C₂₅H₁₇F₂NO₂
• Molecular Weight: 401.41654
• Mol File: 154015-73-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 10-Fluoro-3-(2-fluorophenyl)-6,7-dihydro-5H-benz[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 10-Fluoro-3-(2-fluorophenyl)-6,7-dihydro-5H-benz[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid(154015-73-3)
• EPA Substance Registry System: 10-Fluoro-3-(2-fluorophenyl)-6,7-dihydro-5H-benz[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid(154015-73-3)

Safety Data

• Hazardous Substances Data: 154015-73-3(Hazardous Substances Data)

Upstream product

• 213540-89-7 N-octyl-6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxamide 
• 213541-08-3 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-5H-benzo[6,7]cyclohepta[1,2-b]quinoline-8-carboxylic acid 
• 406219-68-9 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid 
• 213541-12-9 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid 
• 213541-06-1 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-hydroxymethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline 
• 213541-04-9 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline 
• 213541-03-8 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-hydroxymethyl-6-fluoroquinoline 
• 213541-01-6 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline 
• 213541-05-0 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-chloromethyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline 
• 213541-02-7 2-[4-(2-fluorophenyl)phenyl]-3-(2-methoxycarbonylethyl)-4-chloromethyl-6-fluoroquinoline 
• 213541-07-2 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5-oxo-8-formyl-5H-benzo[6,7]cyclohepta[1,2-b]quinoline 
• 406219-65-6 5-(2'-fluoro-biphenyl-4-yl)-5-oxo-pentanoic acid methyl ester 
• 321-60-8 2-fluorobiphenyl 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 

Relevant articles and documents

Synthetic study on novel immunosuppressant KF20444.

The two new synthetic routes to 6,7-dihydro-10-fluoro-3-(2-fluorophenyl)-5H- benzo[6,7]cyclohepta[1,2-b]-quinoline-8-carboxylic acid (1), a novel immunosuppressant KF20444, are described. The seven-membered ring construction from 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-4-chloromethyl-6-fluoroquinoline (17c) was achieved by intramolecular Friedel-Crafts reaction under acidic conditions as the key step. Subsequently, the oxidation of 4-chloromethyl group followed by reduction of carbonyl group on the seven-membered ring afforded 1. This route provides a new method for the synthesis of 1.