154016-47-4

Basic information

• Product Name: (5-PHENYLISOXAZOL-3-YL)METHYLAMINE
• Synonyms: C-(5-PHENYL-ISOXAZOL-3-YL)-METHYLAMINE;CBI-BB ZERO/004801;(5-PHENYLISOXAZOL-3-YL)METHYLAMINE;AKOS PAO-1454;1-(5-Phenyl-1,2-oxazol-3-yl)methanamine;3-Isoxazolemethanamine, 5-phenyl-;(5-Phenylisoxazol-3-yl)MethanaMine
• CAS NO: 154016-47-4
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.2
• EINECS: 201-215-5
• Mol File: 154016-47-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.7°C
• Appearance: /
• Density: 1.155g/cm³
• Vapor Pressure: 7.73E-05mmHg at 25°C
• Refractive Index: 1.573
• PKA: 7.35±0.29(Predicted)
• CAS DataBase Reference: (5-PHENYLISOXAZOL-3-YL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-PHENYLISOXAZOL-3-YL)METHYLAMINE(154016-47-4)
• EPA Substance Registry System: (5-PHENYLISOXAZOL-3-YL)METHYLAMINE(154016-47-4)

Safety Data

• Hazardous Substances Data: 154016-47-4(Hazardous Substances Data)

Usage

General Description

(5-Phenylisoxazol-3-yl)methylamine is a chemical compound with the molecular formula C9H9N3O. It is an amine derivative that contains a phenylisoxazole group, which is a five-membered heterocyclic ring containing oxygen and nitrogen atoms. (5-PHENYLISOXAZOL-3-YL)METHYLAMINE has potential applications in medicinal chemistry and drug development due to its structural features. It may be used as a building block in the synthesis of various pharmaceuticals and bioactive compounds. Additionally, its unique chemical structure makes it a valuable tool for studying the reactivity and biological activity of isoxazole-containing molecules.

InChI:InChI=1/C10H10N2O/c11-7-9-6-10(13-12-9)8-4-2-1-3-5-8/h1-6H,7,11H2

Upstream product

• 154016-52-1 3-(azidomethyl)-5-phenylisoxazole 
• 1619-37-0 (5-phenylisoxazol-3-yl)methanol 
• 7063-99-2 ethyl 5-phenylisoxazole-3-carboxylate 
• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 98-86-2 acetophenone 
• 154016-50-9 3-(bromomethyl)-5-phenylisoxazole 
• 14731-10-3 3-(chloromethyl)-5-phenylisoxazole 

Relevant articles and documents

Synthesis of 5-Arylisoxazole and 4,5-Dichloroisothiazole Amino-Substituted Derivatives and Their Biological Activity

Abstract: A series of amino derivatives of 5-arylisoxazoles and 4,5-dichloroisothiazole with primary and secondary amino groups was synthesized. 3-Aminomethyl-5-arylisoxazol-3-ylmethanamines were obtained on the basis of 5-aryl-3-(chloromethyl)isoxazoles using the Gabriel phthalimide method. 5-Arylisoxazol-3-yl- and 4,5-dichloroisothiazol-3-ylallylamines were synthesized in two ways: reduction of azomethines obtained by condensation of 5-arylisoxazolyl- and 4,5-dichloroisothiazolyl-3-carbaldehydes with allylamine, and by nucleophilic substitution of the chlorine atom in 3-chloromethyl derivatives of the corresponding azoles by reaction with allylamine. Amides and sulfonamides of azolylallylamines were synthesized. Some of the compounds obtained showed antibacterial and fungicidal activity.

Regioselective syntheses of 3-aminomethyl-5-substituted isoxazoles: A facile and chemoselective reduction of azide to amino by sodium borohydride using 1,3-propanedithiol as a catalyst

A series of isoxazole azides were reduced selectively to isoxazole amines in quantitative yield by sodium borohydride using 1,3-propanedithiol as a catalyst.