154044-74-3 Usage
Description
N-Des-t-boc-N-2-[2-methyl-1-(4-methoxyphenyl)methoxy]propyloxycarbonxyl-7,10-O-bis[(2,2,2-trichloroethyl)oxy]carbonyl Docetaxel is a complex organic compound that serves as an intermediate in the synthesis of metabolites of Docetaxel, an antineoplastic agent. It is characterized by its white solid appearance and plays a crucial role in the production of major human metabolites of Docetaxel.
Uses
Used in Pharmaceutical Industry:
N-Des-t-boc-N-2-[2-methyl-1-(4-methoxyphenyl)methoxy]propyloxycarbonxyl-7,10-O-bis[(2,2,2-trichloroethyl)oxy]carbonyl Docetaxel is used as an intermediate in the synthesis of metabolites for Docetaxel, an antineoplastic agent. Its primary application is in the development and production of cancer-fighting drugs, specifically those targeting solid malignancies.
Used in Research and Development:
In addition to its role in the pharmaceutical industry, this compound is also utilized in research and development for the study of Docetaxel's metabolites and their potential effects on cancer treatment. This helps scientists and researchers better understand the drug's mechanism of action and improve its efficacy in cancer therapy.
Chemical Properties:
N-Des-t-boc-N-2-[2-methyl-1-(4-methoxyphenyl)methoxy]propyloxycarbonxyl-7,10-O-bis[(2,2,2-trichloroethyl)oxy]carbonyl Docetaxel is a white solid, indicating its stable and solid-state nature at room temperature. This property is essential for its use in the synthesis of Docetaxel metabolites and its application in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 154044-74-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,0,4 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 154044-74:
(8*1)+(7*5)+(6*4)+(5*0)+(4*4)+(3*4)+(2*7)+(1*4)=113
113 % 10 = 3
So 154044-74-3 is a valid CAS Registry Number.
154044-74-3Relevant articles and documents
Partial synthesis of major human metabolites of docetaxel
Commercon, Alain,Bourzat, Jean-Dominique,Bezard, Daniel,Vuilhorgne, Marc
, p. 10289 - 10298 (2007/10/02)
The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, i.e. compounds 3, 4a,b and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.
