15414-60-5

Basic information

• Product Name: 5-bromo-5'-O-trityl-2'-deoxyuridine
• Synonyms: 5-bromo-5'-O-trityl-2'-deoxyuridine
• CAS NO: 15414-60-5
• Molecular Weight: 549.421
• Mol File: 15414-60-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-bromo-5'-O-trityl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-5'-O-trityl-2'-deoxyuridine(15414-60-5)
• EPA Substance Registry System: 5-bromo-5'-O-trityl-2'-deoxyuridine(15414-60-5)

Safety Data

• Hazardous Substances Data: 15414-60-5(Hazardous Substances Data)

Upstream product

• 14270-73-6 O^5'-trityl-2'-deoxy-uridine 
• 76-83-5 trityl chloride 
• 951-78-0 2'-deoxyuridine 
• 59-14-3 5-bromo-2'-deoxyuridine 

Downstream Products

• 130328-03-9 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester> dihydrochloride 
• 130328-02-8 5-bromo-2'-deoxyuridine 3'-ethyl>glycyl ester> 
• 130328-01-7 5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester> 
• 130327-98-9 5-bromo-5'-trityl-2'-deoxyuridine 3'-ethyl>glycyl ester> 

Relevant articles and documents

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Cyclization-Activated Prodrugs. Basic Esters of 5-Bromo-2'-deoxyuridine

Some 3'- and 5'-glycyl> esters of 5-bromo-2'-deoxyuridine were prepared and evaluated in vitro as progenitors of the parent alcohol.The sters proved to be relatively stable at low pH but released 5-bromo-2'-deoxyuridine cleanly at rates which were pH and structure dependent.These basic esters are examples of cyclization-activated prodrugs in which generation of active drug is not linked to enzymatic cleavage but rather results from an intramolecular cyclization-elimination reaction.