1541987-83-0

Basic information

• Product Name: 4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile
• Synonyms: 4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile
• CAS NO: 1541987-83-0
• Molecular Weight: 270.247
• Mol File: 1541987-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile(1541987-83-0)
• EPA Substance Registry System: 4-[[(6-amino-5-nitropyridin-2-yl)oxy]methyl]benzonitrile(1541987-83-0)

Safety Data

• Hazardous Substances Data: 1541987-83-0(Hazardous Substances Data)

Upstream product

• 874-89-5 4-Cyanobenzyl alcohol 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 

Downstream Products

• 1541987-85-2 4-[[(5,6-diaminopyridin-2-yl)oxy]methyl]benzonitrile 
• 1541988-28-6 4-[5-[(4-cyanobenzyl)oxy]-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile 
• 1541988-67-3 4-[5-[(4-cyanobenzyl)oxy]-1-methyl-1H-imidazo[4,5-b]pyridin-2-yl]benzonitrile 
• 1541987-89-6 N-[2-amino-6-[(4-cyanobenzyl)oxy]pyridin-3-yl]-2-(4-cyanophenoxy)acetamide 
• 1541987-92-1 4-[[5-(4-cyanobenzyloxy)-3H-imidazo[4,5-b]pyridin-2-yl]methoxy]benzonitrile 
• 1541987-98-7 4-[5-[(4-cyanobenzyl)oxy]-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile 
• 1541988-32-2 3-[5-[(4-cyanobenzyl)oxy]-3H-imidazo[4,5-b]pyridin-2-yl]benzonitrile 

Relevant articles and documents

Design and synthesis of heterocyclic cations for specific DNA recognition: From AT-rich to mixed-base-pair DNA sequences

The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove. Modifications were introduced in the original compound to include an H-bond accepting group to specifically recognize the G-NH that projects into the minor groove. Therefore, a series of heterocyclic cations substituted with an azabenzimidazole ring has been designed and synthesized for mixed-base-pair DNA recognition. The most successful compound, 12a, had an azabenzimidazole to recognize G and additional modifications for general minor groove interactions. It binds to the DNA site -AAAGTTT- more strongly than the -AAATTT- site without GC and indicates the design success. Structural modifications of 12a generally weakened binding. The interactions of the new compound with a variety of DNA sequences with and without GC base pairs were evaluated by thermal melting analysis, circular dichroism, fluorescence emission spectroscopy, surface plasmon resonance, and molecular modeling.