154229-20-6 Usage
Description
Anhydro Abiraterone, an impurity of Abiraterone (A108490), is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17). It plays a significant role in the development and progression of androgen-dependent prostate cancer by inhibiting the enzyme CYP17, which is crucial for androgen synthesis. Anhydro Abiraterone is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
Uses
Used in Pharmaceutical Industry:
Anhydro Abiraterone is used as a potential drug for the treatment of androgen-dependent prostate cancer. It functions by inhibiting the enzyme CYP17, which is essential for androgen synthesis, thereby disrupting the growth and progression of prostate cancer cells.
Anhydro Abiraterone is used as a research compound for the development of novel therapeutic strategies against androgen-dependent prostate cancer. Its role in inhibiting the enzyme CYP17 makes it a valuable candidate for further investigation and potential clinical application in the treatment of this specific type of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 154229-20-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,2,2 and 9 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 154229-20:
(8*1)+(7*5)+(6*4)+(5*2)+(4*2)+(3*9)+(2*2)+(1*0)=116
116 % 10 = 6
So 154229-20-6 is a valid CAS Registry Number.
154229-20-6Relevant articles and documents
17-substituted steroids useful in cancer treatment
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, (2008/06/13)
Compounds of the general formula (1) STR1 wherein X represents the residue of the A, B and C rings of a steroid, R represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, R 14 represents a hydrogen atom and R 15 represents a hydrogen atom or an alkyl or alkoxy group of 1-4 carbon atoms, or a hydroxy or alkylcarbonyloxy group of 2 to 5 carbon atoms or R 14 and R 15 together represent a double bond, and R 16 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, in the form of the free bases or phannaceutically acceptable acid addition salts, are useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent disorders such as breast cancer.
