154243-34-2

Basic information

• Product Name: Benzenepropanoic acid, 2-chloro-b-hydroxy-a-methylene-, methyl ester
• CAS NO: 154243-34-2
• Molecular Formula: C11H11ClO3
• Molecular Weight: 226.66
• Mol File: 154243-34-2.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 2-chloro-b-hydroxy-a-methylene-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 2-chloro-b-hydroxy-a-methylene-, methyl ester(154243-34-2)
• EPA Substance Registry System: Benzenepropanoic acid, 2-chloro-b-hydroxy-a-methylene-, methyl ester(154243-34-2)

Safety Data

• Hazardous Substances Data: 154243-34-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 89-98-5 2-chloro-benzaldehyde 
• 140-88-5 ethyl acrylate 
• 1132641-30-5 methyl 2-((tert-butoxycarbonyloxy)(2-chlorophenyl)methyl)acrylate 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 364633-50-1 3-(2-chlorophenyl)-2-methylacrylic acid methyl ester 
• 1255193-98-6 methyl (Z)-3-(2-chlorophenyl)-2-(isothioureidomethyl)-2-propenoate hydrobromide 
• 1255194-36-5 (5Z)-2-amino-[5-(2-chlorobenzylidene)]-5,6-dihydro-1,3-thiazin-4-one 
• 330442-80-3 methyl (2Z)-2-(bromomethyl)-3-(2-chlorophenyl)prop-2-enoate 
• 1132641-30-5 methyl 2-((tert-butoxycarbonyloxy)(2-chlorophenyl)methyl)acrylate 
• 221086-92-6 2-((2-chlorophenyl)(hydroxy)methyl)acrylic acid 
• 1415989-49-9 5-chloroquinoline-3-carboxylic acid methyl ester 

Relevant articles and documents

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

On the tandem Morita-Baylis-Hillman/transesterification processes. Mechanistic insights for the role of protic solvents

Despite the remarkable rate acceleration under protic solvents such as alcohols and water, the use of acrylates as activated alkenes places a problem due to the possibility of ester hydrolysis or transesterification. Therefore, the tandem transesterification/Morita-Baylis-Hillman (MBH) reactions were investigated by ESI(+)-MS/(MS) and 1H NMR techniques. For the first time, the MBH back-reaction was fully examined by ESI(+)-MS/(MS) using labelling reagents revealed the complex equilibrium involving the Michael-type addition step of DABCO to acrylate. C- and O-protonation were observed at this stage, showing the transesterification process occurs previous to the aldol step, which is the rate-determining step of the mechanism. At this stage, a short-lived tetrahedral intermediate might be involved and should be considered in these processes.

Design, synthesis and evaluation of 3-arylidene azetidin-2-ones as potential antifungal agents against Alternaria solani Sorauer

A new concise and facile method was explored to synthesize a collection of new 3-arylidene azetidin-2-ones, which could be regarded as the derivatives of the hybrid scaffold of bioactive natural cinnamamide and heterocycle azetidi-2-one. The structures of