15430-94-1Relevant articles and documents
Enantiomerically Pure, Highly Functionalized Tetrahydrofurans from Simple Carbohydrate Precursors
Lundt, Inge,Frank, Holger
, p. 13285 - 13298 (2007/10/02)
6-Bromo-6-deoxy-1,4-aldonolactones and 6-bromo-6-deoxy-alditols with D-galacto, D-altro-, D-manno- and D-ido-configuration were selectively converted into hydroxylated tetrahydrofuran derivatives by simple heating in water.The 6-bromo-6-deoxy-altritol (10) and 6-bromo-6-deoxy-D-iditol (25) reacted even at room temperature.Likewise, 6-bromo-2,6-dideoxy-aldonolactones with D-arabino- (29) and D-lyxo-configuration (31) gave the corresponding 2-deoxy-3,6-anhydride, when heated in water.The rate of formation of the furan ring by intramolecular nucleophilic substitution was determined by the conformation of the bromopolyols in water.
Influence of the chemical structure on the biological endency of cytostatic compounds related to dibromomannitol. I. Structure-activity correlations.
Institoris,Horvath,Csanyi
, p. 145 - 149 (2007/10/12)
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