15433-80-4

Basic information

• Product Name: (5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL
• Synonyms: 2-FURANMETHANOL, 5-[(DIETHYLAMINO)METHYL]-;AKOS ISYA01075;(5-((diethylaMino)Methyl)furan-2-yl)Methanol;(5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL
• CAS NO: 15433-80-4
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.25
• Mol File: 15433-80-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 255.52°C at 760 mmHg
• Flash Point: 108.335°C
• Appearance: /
• Density: 1.043g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL(15433-80-4)
• EPA Substance Registry System: (5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL(15433-80-4)

Safety Data

• Hazardous Substances Data: 15433-80-4(Hazardous Substances Data)

Usage

Description

(5-[(DIETHYLAMINO)METHYL]-2-FURYL)METHANOL, also known as DEAMF, is an organic compound with the molecular formula C13H19NO2. It is a colorless liquid at room temperature and is characterized by its unique chemical structure that includes a diethylamino group and a furyl group. DEAMF is known for its versatile applications in the chemical, pharmaceutical, and medicinal industries due to its properties as a chiral solvent, reagent, and resolving agent.

Uses

Used in Pharmaceutical Industry:
DEAMF is used as a resolving agent for chiral resolution, which is crucial in the development and production of pharmaceuticals. Chiral resolution is essential for obtaining the desired enantiomer of a drug, as different enantiomers can have different biological activities and effects.
Used in Chemical Synthesis:
DEAMF serves as a chiral solvent in various chemical reactions and synthesis processes. Its unique structure allows it to interact with other molecules in a stereoselective manner, which can be beneficial in obtaining specific products with desired stereochemistry.
Used in Agrochemicals and Fragrance Ingredients:
DEAMF is also utilized as a reagent in the synthesis of various compounds, including those used in the agrochemical and fragrance industries. Its ability to influence the stereochemistry of reactions can be advantageous in creating specific compounds with desired properties.
Used in Medicinal and Pharmaceutical Research:
Due to its biological activity, DEAMF may have potential applications in medicinal and pharmaceutical research. It can be explored for its potential therapeutic effects or as a starting point for the development of new drugs or drug candidates.

InChI:InChI=1/C10H17NO2/c1-3-11(4-2)7-9-5-6-10(8-12)13-9/h5-6,12H,3-4,7-8H2,1-2H3

Upstream product

• 24653-40-5 methyl 5-diethylaminomethyl-2-furoate 
• 98-00-0 (2-furyl)methyl alcohol 
• 15433-84-8 5-((diethylamino)methyl)furfural 
• 50-00-0 formaldehyd 
• 109-89-7 diethylamine 
• 1623-88-7 5-chloromethylfurfural 
• 102-53-4 bis-(diethylamino)methane 
• 67-47-0 5-hydroxymethyl-2-furfuraldehyde 

Downstream Products

• 1611490-37-9 4β-N-[5-{((diethylamino)methyl)furan-2-yl}methyl]amido-4'-demethyl-4-desoxypodophyllotoxin 
• 1611490-38-0 4β-N-[5-{((diethylamino)methyl)furan-2-yl}methyl]amido-4-desoxypodophyllotoxin 

Relevant articles and documents

Efficient reductive amination of HMF with well dispersed Pd nanoparticles immobilized in a porous MOF/polymer composite

Aminated derivatives of 5-hydroxymethylfurfural (HMF) and furfural are critical intermediates for the pharmaceutical industry. The state-of-the-art catalysts currently used for these syntheses are mostly homogeneous in nature, motivating the design of rec

Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents

Cancer multidrug resistance (MDR) is a common cause of treatment failure in cancer patients. Increased expression of permeability glycoprotein (P-gp), which is also known as MDR-1, is the main cause of multidrug resistance. Podophyllotoxin derivatives hold great promise in the battle to overcome multidrug resistance, as they can induce cytotoxicity through multiple mechanisms. Here, we synthesized sixteen novel podophyllotoxin derivatives and evaluated their cytotoxicities in human cancer cell lines, HeLa, K562 and K562/A02. Some of these compounds were more potent than etoposide, a clinically relevant inhibitor of DNA repair enzymes. In particular, compound 5p exhibited the most potent activity toward drug-resistant K562/A02 cells, as it robustly inhibited tumor cell proliferation and induced apoptosis. Furthermore, preliminary investigation suggested that 5p inhibited the expression of MDR-1 in K562/A02 cells more effectively than etoposide.

Cholinergic Agents Structurally Related to Furtrethonium. 2. Synthesis and Antimuscarinic Activity of a Series of N--2-furfuryl>dialkylamines

In the first part of this study, devoted to the discovery of selective antimuscarinic agents, (+/-)-N--2-furfuryl>dimethylamine (5a) proved to be at least 20 times more potent in the rat ileum and bladder than in