154345-82-1

Basic information

• Product Name: (D,L)-5-(2-phenyl-1-tert-butyloxycarbonylaminoethyl)-3-(3-pyridyl)-1,2,4-oxadiazole
• Synonyms: (D,L)-5-(2-phenyl-1-tert-butyloxycarbonylaminoethyl)-3-(3-pyridyl)-1,2,4-oxadiazole
• CAS NO: 154345-82-1
• Molecular Weight: 366.42
• Mol File: 154345-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (D,L)-5-(2-phenyl-1-tert-butyloxycarbonylaminoethyl)-3-(3-pyridyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: (D,L)-5-(2-phenyl-1-tert-butyloxycarbonylaminoethyl)-3-(3-pyridyl)-1,2,4-oxadiazole(154345-82-1)
• EPA Substance Registry System: (D,L)-5-(2-phenyl-1-tert-butyloxycarbonylaminoethyl)-3-(3-pyridyl)-1,2,4-oxadiazole(154345-82-1)

Safety Data

• Hazardous Substances Data: 154345-82-1(Hazardous Substances Data)

Upstream product

• 51987-73-6 methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate 
• 1594-58-7 nicotinamide oxime 
• 100-54-9 pyridine-3-carbonitrile 

Relevant articles and documents

1,2,4-Oxadiazole derivatives of phenylalanine: potential inhibitors of substance P endopeptidase

The synthesis and the biological activity of a series of benzyl or aryl substituted 1,2,4-oxadiazole derivatives of phenyl-alanine are described.A base-promoted intermolecular cyclization reaction was performed using racemic tert-butyloxycarbonyl protected phenylalanine methyl ester and an amidoxime.After deprotection of the amino function the compounds were evaluated for their affinity to rat brain NK1-receptors and as inhibitors of a specific substance P cleaving enzyme, substance P endopeptidase (SPE), isolated from human cerebrospinal fluid.The results indicate that several compounds are weak inhibitors of SPE.However, all compounds lacked appreciable NK1-receptor affinity.Keywords: 1,2,4-oxadiazoles / substance P endopeptidase / Phe-Phe mimetics / amide bioisostere / NK1-receptor affinity