15435-71-9Relevant articles and documents
A novel palladium(II) antitumor agent: Synthesis, characterization, DFT perspective, CT-DNA and BSA interaction studies via in-vitro and in-silico approaches
Feizi-Dehnayebi, Mehran,Dehghanian, Effat,Mansouri-Torshizi, Hassan
, (2020/12/07)
Since numerous people annually pass away due to cancer, research in this field is essential. Thus a newly made and water like palladium(II) complex of formula [Pd(phen)(acac)]NO3, where phen is 1,10-phenanthroline and acac is acetylacetonato ligand, has been synthesized by the reaction between [Pd(phen)(H2O)2](NO3)2 and sodium salt of acetylacetone in the molar ratio of 1:1. It has been structurally characterized via the methods such as conductivity measurement, elemental analysis and spectroscopic methods (FT-IR, UV–Vis and 1H NMR). The geometry optimization of this complex at the DFT level of theory reveals that Pd(II) atom is situated in a square-planar geometry. The complex has been screened for its antitumor activity against K562 cancer cells which demonstrated efficacious activity. The interaction of above palladium(II) complex with CT-DNA as a target molecule for antitumor agents and BSA as a transport protein was studies by a variety of techniques. The results of UV–Vis absorption and fluorescence emission indicated that the Pd(II) complex interacts with EB + CT-DNA through hydrophobic and with BSA by hydrogen bonding and van der Waals forces at very low concentrations. In these processes, the fluorescence quenching mechanism of both the macromolecules seems to be the combined dynamic and static. The interaction was further supported for CT-DNA by carrying out the gel electrophoresis and viscosity measurement and for BSA by the circular dichroism and F?rster resonance energy transfer experiments. Furthermore, results of partition coefficient determination showed that the [Pd(phen)(acac)]NO3 complex is more lipophilic than that of cisplatin. Moreover, molecular docking simulation confirms the obtained results from experimental tests and reveals that the complex tends to be located at the intercalation site of DNA and Sudlow's site I of BSA.
Method for synthesizing ruthenium (III) acetylacetonate (by machine translation)
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Paragraph 0011; 0025; 0033; 0035-0040; 0042-0044, (2020/09/10)
A method for synthesizing the ruthenium (III) acetylacetonate, which comprises the following steps of: a, dissolving the hydrated ruthenium trichloride in water, reacting with the base to obtain the ruthenium salt solution; b, reacting the ruthenium salt solution with the acetyl acetonate solution; b, purifying the ruthenium salt solution and the acetyl acetonate solution under heating conditions; and obtaining the total reaction equation of the ruthenium (III) chloride solution and the chloride ion content _AOMARKENCODTX0AO_ 80 - 90% 50 ppm. In the formula, HL is a strong acid of a non-coordinating anion acac is acetyl acetonate. M is Na or K; the content of impurity chloride ions is reduced while the high yield of ruthenium (III) acetylacetonate is guaranteed, the product quality is improved, and industrial production is facilitated. (by machine translation)
Oxidative Mechanochemistry: Direct, Room-Temperature, Solvent-Free Conversion of Palladium and Gold Metals into Soluble Salts and Coordination Complexes
Do, Jean-Louis,Tan, Davin,Fri??i?, Tomislav
supporting information, p. 2667 - 2671 (2018/02/06)
Noble metals are valued, critical elements whose chemical activation or recycling is challenging, and traditionally requires high temperatures, strong acids or bases, or aggressive complexation agents. By using elementary palladium and gold, demonstrated here is the use of mechanochemistry for noble-metal activation and recycling by mild, clean, solvent-free, and room-temperature chemistry. The process leads to direct, efficient, one-pot conversion of the metals, including spent catalysts, into either simple water-soluble salts or metal–organic catalysts.
