154382-30-6

Basic information

• Product Name: β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester
• CAS NO: 154382-30-6
• Molecular Weight: 260.333
• Mol File: 154382-30-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester(154382-30-6)
• EPA Substance Registry System: β-oxo-1-phenylcyclopentanepropanoic acid ethyl ester(154382-30-6)

Safety Data

• Hazardous Substances Data: 154382-30-6(Hazardous Substances Data)

Upstream product

• 77-55-4 1-phenyl-1-cyclopentanecarboxylic acid 
• 6148-64-7 ethyl potassium malonate 
• 530-62-1 1,1'-carbonyldiimidazole 
• 37517-78-5 magnesium bis(3-ethoxy-3-oxopropanoate) 

Downstream Products

• 4046-09-7 1-(1-phenylcyclopentyl)ethan-1-one 

Relevant articles and documents

Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel β-ketoamides as hypocholesterolemic agents

A study of structure-activity relationships of substituted β-ketoamide ACAT inhibitors I and II was performed. The results of this study suggest that whereas the β-keto group was tolerated with no loss in activity, β- hydroxy and oxime moieties led to significantly reduced activity in vitro and in vivo. The most potent inhibitor from the acyclic series (I) (11, IC50 = 0.006 μM) contained a C-13 alkyl chain. This compound reduced plasma total cholesterol by 38% and 66% at 3 and 30 mg/kg, respectively, in cholesterol- fed rats. Dimethylation α to the anilide core (5) and subsequent N- methylation of the amide NH (6) decreased in vitro potency significantly. It was also found that high potency was retained with inhibitors which incorporated the carbonyl into a lactam ring (II).