154544-62-4Relevant articles and documents
Synthesis and pharmacological study of new calcium antagonists analogues of cinnarizine and flunarizine
Younes, S.,Baziard-Mouysset, G.,Saqui-Sannes, G. de,Stigliani, J. L.,Payard, M.,et al.
, p. 943 - 948 (1993)
Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro.The diethyl phosphonate group was condensed on substituted , , , , and groups.Despite the presence of the diethyl phosphonate moiety and the benzhydrylpiperazinyl group, both present in potent calcium antagonist structures, only 1 of the 19 synthesis compounds exhibited a calcium antagonistic profile. diethyl phosphonate / benzhydryl piperazine / calcium antagonist