1546-79-8 Usage
Description
1-(Trifluoroacetyl)imidazole is a derivatizing reagent, characterized as a colorless to pink liquid. It is primarily utilized in the chemical synthesis and analysis of various compounds, particularly for the modification of functional groups such as amino groups.
Uses
Used in Chemical Synthesis:
1-(Trifluoroacetyl)imidazole is used as a derivatizing agent for the modification of functional groups like amino groups. This application is crucial in the synthesis of various organic compounds, as it allows for the introduction of specific functional groups, enhancing the reactivity and properties of the target molecules.
Used in Analytical Chemistry:
In analytical chemistry, 1-(Trifluoroacetyl)imidazole is employed as a derivatizing agent to facilitate the analysis of certain compounds. For instance, it has been used to sequentially derivatize functional groups like amino groups in a study demonstrating trimethylsilyl esters of aromatic and aliphatic sulfonic acids. This application aids in the identification, quantification, and structural elucidation of these compounds, which can be particularly useful in research and quality control processes.
Used in Pharmaceutical Industry:
1-(Trifluoroacetyl)imidazole may also find applications in the pharmaceutical industry, where it can be used as a key intermediate in the synthesis of various drug candidates. Its ability to modify functional groups makes it a valuable tool in the development of new medications with improved efficacy, selectivity, and pharmacokinetic properties.
Used in Material Science:
In the field of material science, 1-(Trifluoroacetyl)imidazole can be utilized to modify the properties of polymers and other materials. By introducing specific functional groups, it can enhance the material's performance, such as its mechanical strength, thermal stability, or chemical resistance, depending on the desired application.
Check Digit Verification of cas no
The CAS Registry Mumber 1546-79-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,4 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1546-79:
(6*1)+(5*5)+(4*4)+(3*6)+(2*7)+(1*9)=88
88 % 10 = 8
So 1546-79-8 is a valid CAS Registry Number.
InChI:InChI=1/3FH.Fe.3H2O/h3*1H;;3*1H2/q;;;+3;;;/p-3
1546-79-8Relevant articles and documents
Preparative synthesis of 2,2-dimethyl-5-(trifluoroacetyl)-1,3-dioxane-4,6-dione (2-trifluoroacetyl Meldrum's acid) and 2,2-dimethyl-6-(trifluoromethyl)-4H-1,3-dioxin-4-one and their synthetic usefulness as (trifluoroacetyl)ketene precursors
Sevenard, Dmitri V.,Didenko, Andrey V.,Lorenz, Denis,Vorobiev, Michael,Stelten, Johannes,Dülcks, Thomas,Sosnovskikh, Vyacheslav Ya.
, p. 1495 - 1502 (2017/02/18)
A simple and reliable method for the preparation of 2,2-dimethyl-5-(trifluoroacetyl)-1,3-dioxane-4,6-dione and 2,2-dimethyl-6-(trifluoromethyl)-4H-1,3-dioxin-4-one on a multigram scale was developed. These (trifluoroacetyl)ketene precursors were used in the hetero-Diels-Alder reaction with dialkylcyanamides and 1-ethoxyprop-1-yne, as well as in some reactions with nucleophiles.
EFFICIENT OXYGENATION OF THIOPHOSPHORYL AND SELENOPHOSPHORYL GROUPS USING TRIFLUOROACETIC ANHYDRIDE
Helinski, Jan,Skrzypczynski, Zbigniew,Wasiak, Jacek,Michalski, Jan
, p. 4081 - 4084 (2007/10/02)
Trifluoroacetic anhydride reacts with organophosphorus compounds containing thiophosphoryl and selenophosphoryl groups converting them in high yield to the corresponding oxygenated systems.
