15460-16-9Relevant articles and documents
A scalable and green one-minute synthesis of substituted phenols
Elumalai, Vijayaragavan,Hansen, J?rn H.
, p. 40582 - 40587 (2020/11/18)
A mild, green and highly efficient protocol was developed for the synthesis of substituted phenols via ipso-hydroxylation of arylboronic acids in ethanol. The method utilizes the combination of aqueous hydrogen peroxide as the oxidant and H2O2/HBr as the reagent under unprecedentedly simple and convenient conditions. A wide range of arylboronic acids were smoothly transformed into substituted phenols in very good to excellent yields without chromatographic purification. The reaction is scalable up to at least 5 grams at room temperature with one-minute reaction time and can be combined in a one-pot sequence with bromination and Pd-catalyzed cross-coupling to generate more diverse, highly substituted phenols.
1-Benzyl-4-aza-1-azoniabicyclo[2.2.2]octane tribromide as a regenerable and useful reagent for bromination of phenols under mild conditions
Hajipour, Abdol R.,Pourmousavi, Seied A.,Ruoho, Arnold E.
, p. 796 - 800 (2007/10/03)
1-Benzyl-4-aza-1-azoniabicyclo[2.2.2]octane tribromide has been examined over several phenolic compounds under mild conditions. The reaction gives brominated phenols in good to excellent yields. Straightforward work-up of the reaction yields pure products in several cases.
A controlled and selective bromination of phenols by benzyltriphenylphosphonium tribromide
Hajipour, Abdol Reza,Mallakpour, Shadpour E.,Imanieh, Hossein,Pourmousavi, Seied A.
, p. 272 - 275 (2007/10/03)
Reactions of phenols with benzyltriphenylphosphonium tribromide in dichloromethane-methanol mixture (2:1) gave mono, di and tri brominated phenols at room temperature with high selectivity and good yields.
