15462-03-0

Basic information

• Product Name: 3',4'-dimethoxyphenylglyoxal
• Synonyms: 3',4'-dimethoxyphenylglyoxal
• CAS NO: 15462-03-0
• Molecular Weight: 194.187
• Mol File: 15462-03-0.mol
• Article Data: 29

Chemical Properties

• CAS DataBase Reference: 3',4'-dimethoxyphenylglyoxal(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-dimethoxyphenylglyoxal(15462-03-0)
• EPA Substance Registry System: 3',4'-dimethoxyphenylglyoxal(15462-03-0)

Safety Data

• Hazardous Substances Data: 15462-03-0(Hazardous Substances Data)

Upstream product

• 10535-17-8 1-(3,4-dimethoxyphenyl)-2-(methoxyphenoxy)propane-1,3-diol 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 91-16-7 1,2-dimethoxybenzene 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 163428-90-8 2,2-dihydroxy-1-(3,4-dimethoxyphenyl)ethan-1-one 
• 6380-23-0 3,4-dimethoxystyrene 

Downstream Products

• 1227411-42-8 3-(2-(3,4-dimethoxyphenyl)-1-hydroxy-2-oxoethyl)-3-methylindolin-2-one 
• 1638141-14-6 C₂₂H₁₈N₂O₅ 
• 1638141-33-9 C₂₂H₂₀N₂O₄ 
• 1241555-97-4 C₁₀H₁₂N₂O₃ 
• 1187829-40-8 (3,4‐dimethoxyphenyl)[4‐(3,4‐dimethoxyphenyl)‐1H‐imidazol‐2‐yl]methanone 
• 76177-53-2 2-(3,4-dimethoxyphenyl)pyrazine 
• 935479-82-6 2,2-bis-benzyloxy-1-(3,4-dimethoxy-phenyl)-ethanone 

Relevant articles and documents

Polycarboxylated compounds and compositions containing same

Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on β-O-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. The oxidation results in polycarboxylated lignin in the form of a polymeric β-hydroxy acid. The polymeric β-hydroxy acid has a high loading of carboxylic acid and can be isolated in acid form, deprotonated, and/or converted to a salt. The β-hydroxy acid, anion, or salt can also be subjected to acidolysis to generate various aromatic monomers or oligomers. The initial oxidation of lignin to the polycarboxylated form renders the lignin more susceptible to acidolysis and thereby enhances the yield of aromatic monomers and oligomers obtained through acidolysis.

Visible-Light-Induced Regioselective Dicarbonylation of Indolizines with Oxoaldehydes via Direct C-H Functionalization

A metal-free system for regioselective dehydrogenative cross-couplings between indolizines and oxoaldehydes catalyzed by visible light under mild conditions has been described. As an atom economical and eco-friendly protocol, the reaction proceeds in good yields using inexpensive, readily available visible-light sources and the environmentally friendly oxidant oxygen. Various valuable 1,2-dicarbonyl derivatives attached to an indolizine core were easily accessed by the direct dicarbonylation of the sp2 C-H bond.

Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. Structure activity relationship studies, docking studies to on X-ray crystal structure of AChE with PDB code 1B41, and adsorption, distribution, metabolism, and excretion (ADME) predictions were performed. The synthesized core skeleton was bound to important regions of the active site of AChE such as the peripheral anionic site (PAS), oxyanion hole (OH), and anionic subsite (AS). Selectivity of the reported test compounds was calculated and enzyme kinetic studies revealed that they behave as competitive inhibitors, while two of the test compounds showed noncompetitive inhibitory behavior. ADME predictions revealed that the synthesized molecules might pass through the blood brain barrier and intestinal epithelial barrier and circulate freely in the blood stream without binding to human serum albumin. While the toxicity of one compound on the WS1 (skin fibroblast) cell line was 1790 μM, its toxicity on the SH-SY5Y (neuroblastoma) cell line was 950 μM.