154698-93-8

Basic information

• Product Name: 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide
• Synonyms: 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide;2-((tert-Butyldiphenylsilyl)
• CAS NO: 154698-93-8
• Molecular Formula: C₂₀H₂₇NO₃Si
• Molecular Weight: 357.51878
• Mol File: 154698-93-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 395.0±48.0 °C(Predicted)
• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide(154698-93-8)
• EPA Substance Registry System: 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide(154698-93-8)

Safety Data

• Hazardous Substances Data: 154698-93-8(Hazardous Substances Data)

Usage

General Description

2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide is a chemical compound with the formula C22H29NO3Si. It is a silyl ether derivative of N-methoxy-N-methylacetamide, and the tert-butyldiphenylsilyl group serves as a protective group in organic synthesis. 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide is commonly used in the protection of nitrogen-containing functional groups in organic chemistry reactions. It is a stable, crystalline solid that is sparingly soluble in water but soluble in organic solvents such as dichloromethane and ethyl acetate. 2-((tert-Butyldiphenylsilyl)oxy)-N-methoxy-N-methylacetamide is an important reagent in organic synthesis for the selective protection of amine functional groups.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 154698-92-7 methyl 2-((tert-butyl(diphenyl)silyl)oxy)acetate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 76271-74-4 2-((t-butyldiphenylsilyl)oxy)acetic acid 

Downstream Products

• 154698-94-9 (tert-Butyldiphenylsiloxy)methyl 2-<(methoxymethyl)oxy>-4-methylphenyl ketone 
• 158531-86-3 (tert-Butyldiphenylsiloxy)methyl 3,4-dimethoxyphenyl ketone 
• 159419-44-0 1-(tert-butyldiphenylsiloxy)hex-5-en-2-one 
• 200571-96-6 (E)-1-(tert-Butyl-diphenyl-silanyloxy)-7,7-dimethoxy-4-methyl-hept-3-en-2-one 
• 204916-61-0 1-(tert-butyl-diphenyl-silanyloxy)-but-3-en-2-one 
• 193292-63-6 7-[(tert-butyldimethylsilyl)oxy]-1-[(tert-butyldiphenylsilyl)oxy]-3-heptyn-2-one 
• 193292-62-5 (E)-7-[(tert-butyldimethylsilyl)oxy]-1-[(tert-butyldiphenylsilyl)oxy]-4-methyl-3-hepten-2-one 
• 934631-60-4 1-(tert-butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,5-dimethyl-hex-3-yn-2-one 
• 934631-61-5 1-(tert-butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5,5-dimethyl-hex-3-yn-2-ol 
• 477893-40-6 tert-butyl-(2-methylene-but-3-enyloxy)-diphenyl-silane 
• 335455-42-0 (3E,8Z,10Z)-10-(tert-Butyl-diphenyl-silanyloxymethyl)-8-methyl-dodeca-3,8,10-trien-2-one 
• 263387-46-8 (R)-1-(tert-Butyl-diphenyl-silanyloxy)-5-[(1R,2R,4aS,8aS)-5-(tert-butyl-diphenyl-silanyloxymethyl)-1,2,4a-trimethyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl]-4-hydroxy-3-methylene-pentan-2-one 

Relevant articles and documents

An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing

Autoinducer-2 (AI-2) is a signalling molecule for bacterial inter-species communication. A synthesis of (S)-4,5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2, is described starting from methyl glycolate. The key step was an asymmetric reduction of a ketone with (S)-Alpine borane. This new method was highly reproducible affording DPD for biological tests without contaminants. The biological activity was tested with the previously available assays and compared with a new method using an Escherichia coli reporter strain thus avoiding the use of the pathogenic Salmonella reporter.

A Remarkable Substituent Effect on the Enantioselectivity of Tandem Asymmetric Epoxidation and Enantiospecific Ring Expansion of Cyclopropylidene Alcohols: A New Enantiocontrolled Synthesis of (-)-Debromoaplysin and (-)-Aplysin

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