154722-74-4Relevant articles and documents
Butenolide derivative as well as preparation method and application thereof
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, (2020/07/21)
The invention discloses a butenolide compound as well as a preparation method and an application thereof. The butenolide derivative has the inhibitory activity of protein tyrosine phosphatase 1B (PTP1B), improves insulin resistance of HepG2 cells, generates a remarkable hypoglycemic effect and can be used for preparing a medicine for treating diabetes mellitus.
Novel 4,5-diaryl-3-hydroxy-2(5H)-furanones as anti-oxidants and anti-inflammatory agents
Weber, Valérie,Coudert, Pascal,Rubat, Catherine,Duroux, Eliane,Vallée-Goyet, Danielle,Gardette, Daniel,Bria, Marc,Albuisson, Eliane,Leal, Fernand,Gramain, Jean-Claude,Couquelet, Jacques,Madesclaire, Michel
, p. 1647 - 1658 (2007/10/03)
In order to study the effect of phenol moieties on biological activities of ascorbic acid derivatives, we synthesized 13 novel 4,5-diaryl-3-hydroxy-2(5H)-furanones 5a-m with various substitution patterns. Compound 5g bearing a 2,3-dihydroxy phenyl ring on
Syntheses and novel bioactivities of artificial leaf-opening substances of Lespedeza cuneata G. Don, designed for the bioorganic studies of nyctinasty
Ueda, Minoru,Sawai, Yoshiyuki,Yamamura, Shosuke
, p. 10925 - 10936 (2007/10/03)
Potassium lespedezate (1) is the leaf-opening substance of a nyctinastic plant, Lespedeza cuneata G. Don. We have synthesized two sugar-derivatives of 1, potassium galactolespedezate (4) and mannolespedezate (6). Both 4 and 6 were quite effective for the leaf-opening of Cassia. mimosoides at 8 x 10-7 M, as strong as 1. However, 1 kept the leaf open only for a few days; on the other hand, 4 and 6 kept the leaf open after a week at that concentration. Additionally, remarkable difference was observed in the rate of enzymatic hydrolysis of natural and artificial leaf-opening sustance by using commercially available β-glucosidase. Therefore, 4 and 6 would not be hydrolized in the plant body, and are potentially useful molecular probes for the studies of the control of the nyctinastic leaf-movement by a biological clock.