154821-86-0Relevant articles and documents
A Total Synthesis of the Sesquiterpene Quinone Metachromin-A
Almeida, Wanda P.,Correia, Carlos Roque D.
, p. 1367 - 1370 (2007/10/02)
The first total synthesis of the marine natural product metachromin A was accomplished through a convergent synthesis amenable to the preparation of synthetic analogues.The main features of this synthesis are the introduction the oxygenation at C17 employing a Thiele acetoxylation reaction and a stereoselective Horner-Wadsworth-Emmons coupling of a nonstabilized phosphonate with a methyl ketone derivative to generate the required (E)-trisubstituted double bond.