1548332-51-9

Basic information

• Product Name: (1E,4E)-1-(3-allyl-4-methoxyphenyl)-5-[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one
• Synonyms: (1E,4E)-1-(3-allyl-4-methoxyphenyl)-5-[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one
• CAS NO: 1548332-51-9
• Molecular Weight: 372.387
• Mol File: 1548332-51-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1E,4E)-1-(3-allyl-4-methoxyphenyl)-5-[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1E,4E)-1-(3-allyl-4-methoxyphenyl)-5-[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one(1548332-51-9)
• EPA Substance Registry System: (1E,4E)-1-(3-allyl-4-methoxyphenyl)-5-[2-(trifluoromethyl)phenyl]penta-1,4-dien-3-one(1548332-51-9)

Safety Data

• Hazardous Substances Data: 1548332-51-9(Hazardous Substances Data)

Upstream product

• 67483-48-1 3-allyl-4-methoxybenzaldehyde 
• 41052-88-4 4-hydroxy-3-(2-propen-1-yl)benzaldehyde 
• 28090-12-2 4-(3-methyl-but-2-enyloxy)-benzaldehyde 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents

Curcumin has been shown to possess anti-inflammatory activities but has been limited for its low stability and poor bioavailability. We have previously reported four series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MACs). In continuation of our ongoing research, we designed and synthesized 33 novel allylated or prenylated MACs here, and evaluated their anti-inflammatory effects in RAW 264.7 macrophages. A majority of them effectively inhibited the LPS-induced expression of TNF-α and IL-6, especially IL-6. The preliminary SAR and quantitative SAR analysis were conducted. Compound 14q is the most potent analog among them, and exhibits significant protection against LPS-induced death in septic mice. Together, these data present a series of new analogs of curcumin as promising anti-inflammatory agents.