154887-98-6

Basic information

• Product Name: conioidine A
• Synonyms: conioidine A
• CAS NO: 154887-98-6
• Molecular Formula: C22H39NO3
• Molecular Weight: 365.54996
• Mol File: 154887-98-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 481.2°Cat760mmHg
• Flash Point: 244.8°C
• Appearance: /
• Density: 0.969g/cm³
• Vapor Pressure: 2.03E-09mmHg at 25°C
• Refractive Index: 1.479
• PKA: -0.84±0.40(Predicted)
• CAS DataBase Reference: conioidine A(CAS DataBase Reference)
• NIST Chemistry Reference: conioidine A(154887-98-6)
• EPA Substance Registry System: conioidine A(154887-98-6)

Safety Data

• Hazardous Substances Data: 154887-98-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C22H39NO3/c1-5-7-8-9-10-11-12-15-21(24)23-16-13-14-20(23)17-19(4)26-22(25)18(3)6-2/h6,19-20H,5,7-17H2,1-4H3/b18-6+

Upstream product

• 1015843-03-4 tert-butyl (2S)-2-[(2'S)-2'-hydroxypropyl]pyrrolidine-1-carboxylate 
• 1250851-46-7 tert-butyl (2S)-2-(2'-oxopropyl)pyrrolidine-1-carboxylate 
• 49651-33-4 α,β-dimethyl acryloyl chloride 
• 56502-01-3 (2S)-1-tert-butoxycarbonyl-2-carboxymethylpyrrolidine 
• 1034128-58-9 (S)-tert-butyl 2-(2-(methoxy(methyl)amino)-2-oxoethyl)pyrrolidine-1-carboxylate 
• 142253-50-7 (S)-2-cyanomethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 1202039-22-2 (2S,2'R)-1-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propan-2-ol 
• 1202039-19-7 (R)-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]propanone 
• 201039-13-6 (R)-2-cyanomethyl pyrrolidine-1-carboxylic acid, tert-butyl ester 
• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1202039-17-5 N-methoxy-N-methyl (R)-2-[N(1')-(tert-butoxycarbonyl)-pyrrolidin-2'-yl]ethanamide 
• 128510-88-3 tert-butyl (R)-2-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Synthesis and Stereochemical Assignment of Conioidine A: DNA- And HSA-Binding Studies of the Four Diastereomers

Conioidine A (1), isolated in 1993 with unknown relative and absolute configuration, was suggested to be a DNA-binding compound by an indirect technique. Four stereoisomers of conioidine A have been synthesized from d- and l-proline, and the natural product has been identified as possessing (4R,6R) absolute configuration. Binding of the conioidine diastereomers to calf thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by fluorescence spectroscopy and isothermal titration calorimetry (ITC). All stereoisomers display at least an order of magnitude weaker binding to DNA than the control compound netropsin; however, a strong association with HSA was observed for the (4R,6S) stereoisomer.