154925-95-8 Usage
Description
3',5'-Bis-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine is a chemical compound that serves as an intermediate in the preparation of cytidine derivatives. It is characterized by its white to off-white solid appearance.
Uses
Used in Pharmaceutical Industry:
3',5'-Bis-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine is used as an intermediate for the synthesis of cytidine derivatives, which are essential in the development of various pharmaceutical products. Its role in the synthesis process is crucial for creating compounds with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 3',5'-Bis-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine is utilized for studying the properties and reactions of cytidine derivatives. This helps researchers understand the structure-activity relationships and potential applications of these compounds in various fields, including drug discovery and development.
Used in Biochemical Applications:
3',5'-Bis-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine may also be employed in biochemical applications, such as the study of nucleic acid interactions and the development of novel nucleotide analogs with specific biological activities. Its unique structure allows for the exploration of its interactions with enzymes, proteins, and other biomolecules, potentially leading to the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 154925-95-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,9,2 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 154925-95:
(8*1)+(7*5)+(6*4)+(5*9)+(4*2)+(3*5)+(2*9)+(1*5)=158
158 % 10 = 8
So 154925-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H39BrN2O5Si2/c1-20(2,3)30(7,8)27-13-16-15(29-31(9,10)21(4,5)6)11-17(28-16)24-12-14(22)18(25)23-19(24)26/h12,15-17H,11,13H2,1-10H3,(H,23,25,26)/t15?,16-,17-/m1/s1
154925-95-8Relevant articles and documents
Enhanced H-bonding and π-stacking in DNA: A potent duplex-stabilizing and mismatch sensing nucleobase analogue
Lou, Chenguang,Dallmann, Andre,Marafini, Pietro,Gao, Rachel,Brown, Tom
, p. 3836 - 3844 (2014)
X-pyrene is a new nucleic acid duplex stabilizing cytosine analogue that combines enhanced π-stacking, hydrogen bonding and electrostatic interactions to greatly increase the stability of bulged DNA duplexes and DNA/RNA hybrids. X-pyrene is highly selective for guanine as a partner and duplex stability is reduced dramatically when X-pyrene or a neighboring base is mismatched. An NMR study indicates that the pyrene moiety stacks within the helix, and large changes in fluorescence emission on duplex formation are consistent with this. These favorable properties make X-pyrene a promising cytosine analogue for use in a variety of biological applications.
Synthesis of 5-Dihydroxyboryluridine Phosphoramidite and Its Site-Specific Incorporation into Oligonucleotides for Probing Thymine DNA Glycosylase
Kavoosi, Sam,Dey, Debasis,Islam, Kabirul
, p. 6614 - 6618 (2019)
A concise synthetic strategy to 5-dihydroxyboryldexoyuridine (5boU) phosphoramidite has been developed. 5boU was introduced into short oligonucleotides in a site-specific manner, demonstrating compatibility of the boronic acid moiety with standard solid-phase DNA synthesis chemistry. Electrophilic 5boU DNAs inhibited thymine DNA glycosylase, a cancer-relevant DNA-modifying enzyme. We envisage diverse applications of 5boU in organic synthesis, medicinal chemistry, and chemical biology.
Design and synthesis of thalidomide-deoxyribonucleoside chimeras
Suzuki, Shigeru,Yamamoto, Takeshi,Tokunaga, Etsuko,Nakamura, Shuichi,Tanaka, Motohiro,Sasaki, Takuma,Shibata, Norio
supporting information; experimental part, p. 1046 - 1047 (2010/07/05)
Novel thalidomide-deoxyribonucleoside chimeras have been synthesized as potentially safe, thalidomide-based antitumour agents. Copyright