154978-38-8 Usage
Description
6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID is a complex organic compound characterized by its unique molecular structure, which includes a carboxyphenylthio group, a hydroxyl group, and multiple double bonds in its eicosatetraenoic acid chain. 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID exhibits a range of biological activities and has potential applications in various fields due to its structural properties.
Uses
Used in Pharmaceutical Applications:
6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID is used as a therapeutic agent for modulating the activity of CysLT1 and CysLT2 receptors. It acts as a dual non-selective antagonist, with similar IC50 values (20-80 nM) for inhibiting leukotriene (LT) responses in various tissue preparations containing either or both receptors. 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID has potential applications in treating conditions related to leukotriene receptor activation, such as asthma, inflammatory diseases, and other immune-mediated disorders.
Used in Research and Development:
In the field of research, 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID can be used as a tool compound to study the role of CysLT1 and CysLT2 receptors in various biological processes. It can help researchers understand the molecular mechanisms underlying leukotriene receptor signaling and identify potential targets for drug development.
Used in Drug Delivery Systems:
Similar to gallotannin, 6(R)-(4-CARBOXYPHENYLTHIO)-5(S)-HYDROXY-7(E),9(E),11(Z),14(Z)-EICOSATETRAENOIC ACID may also benefit from novel drug delivery systems to enhance its applications and efficacy. By employing carriers such as organic and metallic nanoparticles, the compound's delivery, bioavailability, and therapeutic outcomes can be improved, potentially leading to more effective treatments for various conditions.
Biological Activity
Cysteinyl leukotriene receptor antagonist with equal affinity at both CysLT 1 and CysLT 2 receptors (pK B values are 6.8 and 6.5 respectively). Competitive antagonist of LTC 4 - and LTE 4 -induced contractions of the guinea pig trachea.
references
1. tudhope sr, cuthbert nj, abram ts, jennings ma, maxey rj, thompson am, et al. bay u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. eur j pharmacol 1994,264:317-323.2. muraki m, imbe s, santo h, sato r, sano h, iwanaga t, et al. effects of a cysteinyl leukotriene dual 1/2 receptor antagonist on antigen-induced airway hypersensitivity and airway inflammation in a guinea pig asthma model. int arch allergy immunol 2011,155 suppl 1:90-95.3. wikstrom jonsson e, rosenqvist u, dahlen se. agonist and antagonist activities of the leukotriene analogue bay u9773 in guinea pig lung parenchyma. eur j pharmacol 1998,357:203-211.
Check Digit Verification of cas no
The CAS Registry Mumber 154978-38-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,4,9,7 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 154978-38:
(8*1)+(7*5)+(6*4)+(5*9)+(4*7)+(3*8)+(2*3)+(1*8)=178
178 % 10 = 8
So 154978-38-8 is a valid CAS Registry Number.
