155-16-8

Basic information

• Product Name: 5-fluoro-1-methylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-methyl-; 5-Fluoro-1-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 155-16-8
• Molecular Formula: C₅H₅FN₂O₂
• Molecular Weight: 144.1038
• Mol File: 155-16-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 223.9°C at 760 mmHg
• Flash Point: 89.2°C
• Density: 1.44g/cm³
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: 5-fluoro-1-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-1-methylpyrimidine-2,4(1H,3H)-dione(155-16-8)
• EPA Substance Registry System: 5-fluoro-1-methylpyrimidine-2,4(1H,3H)-dione(155-16-8)

Safety Data

• Hazardous Substances Data: 155-16-8(Hazardous Substances Data)

Usage

General Description

5-fluoro-1-methylpyrimidine-2,4(1H,3H)-dione, also known as flumethasone, is a synthetic corticosteroid that is used as a topical anti-inflammatory and anti-itching agent. It works by inhibiting the production of inflammatory cytokines and enzymes, which reduces swelling, redness, and itching associated with various skin conditions. Flumethasone is commonly used to treat conditions such as eczema, dermatitis, and psoriasis. It is available in various topical formulations, including creams, ointments, and lotions, and is usually applied directly to the affected area of the skin. Side effects may include skin irritation, burning, stinging, or itching at the application site, and prolonged use may lead to skin thinning or changes in skin pigmentation. It is important to use flumethasone exactly as directed by a healthcare professional and to avoid using it on broken or infected skin.

Upstream product

• 615-77-0 1-methyluracil 
• 78948-09-1 acetyl hypofluorite 
• 512-56-1 trimethyl phosphite 
• 51-21-8 5-fluorouracil 
• 74-88-4 methyl iodide 
• 115923-76-7 Acetic acid 5-fluoro-3-methyl-2,6-dioxo-hexahydro-pyrimidin-4-yl ester 
• 118004-31-2 Carbonic acid benzyl ester 5-fluoro-3-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 

Relevant articles and documents

Nucleic acid related compounds. 3. A facile synthesis of 5-fluorouracil bases and nucleosides by direct fluorination.

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Effect of the structure of 1- and 3-methyl-5-fluoropyrimidin-4-ones on H-D exchange in position 6 under conditions of base catalysis

Hydrogen atom in position 6 of 5-fluoro-1-methylpyrimidin-4(1H)-one and its 2-methylsulfan-yl, 2-methoxy and 2-butylamino derivatives is readily replaced by deuterium in 90% methanol-d4 at ～20εC under conditions of base catalysis. The rate of H

The photocycloaddition reactions of uridine and related compounds with 2,3-dimethyl-2-butene

The photochemical reactions of uracil and 5-fluorouracil derivatives with simple alkenes have been investigated. Photocycloaddition of uracil or 5-fluorouracil derivatives and 2,3-dimethyl-2-butene in acetone gave an enantiomeric mixture of cross cycloadducts (4, 7) in moderate yields. Under similar conditions, diastereomers of 4-substituted 7,7,8,8-tetramethyl-cis-2,4-diazabicyclo[4.2.0]octane-3,5-dione nucleosides (14-17) were formed from uridine or 5-fluorouridine derivatives in good yields. The structures and stereochemistry of these cycloadducts of the nucleoside series were elucidated on the basis of the proton nuclear magnetic resonance spectra and X-ray crystallographic analysis.

Application of the Benzyloxycarbonyloxymethyl Moiety to a Protective Group of 5-Fluoroacil. Selective Alkylation of Amide Nitrogen of the Uracil Ring

Selective alkylation of 5-fluorouracil using the benzoyloxycarbonyloxymethyl moiety as a protective group of amide nitrogen of the uracil ring is described.Protection, alkylation and deprotection were carried out in high yields.