1551577-70-8

Basic information

• Product Name: methyl 5-((2-cyclopropylethyl)amino)-3-(2,4-dichlorophenyl)-5-oxopentanoate
• Synonyms: methyl 5-((2-cyclopropylethyl)amino)-3-(2,4-dichlorophenyl)-5-oxopentanoate
• CAS NO: 1551577-70-8
• Molecular Weight: 358.265
• Mol File: 1551577-70-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 5-((2-cyclopropylethyl)amino)-3-(2,4-dichlorophenyl)-5-oxopentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-((2-cyclopropylethyl)amino)-3-(2,4-dichlorophenyl)-5-oxopentanoate(1551577-70-8)
• EPA Substance Registry System: methyl 5-((2-cyclopropylethyl)amino)-3-(2,4-dichlorophenyl)-5-oxopentanoate(1551577-70-8)

Safety Data

• Hazardous Substances Data: 1551577-70-8(Hazardous Substances Data)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 1551577-08-2 3-(2,4-dichlorophenyl)-5-methoxy-5-oxopentanoic acid 
• 62893-54-3 2-(cyclopropyl)ethylamine 
• 103862-84-6 3-(2,4-dichlorophenyl)pentanedioic acid 
• 1551577-02-6 tetramethyl 2-(2,4-dichlorophenyl)propane-1,1,3,3-tetracarboxylate 

Downstream Products

• 1551577-34-4 N¹-(2-cyclopropylethyl)-3-(2,4-dichlorophenyl)-N⁵-hydroxypentanediamide 

Relevant articles and documents

Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain

Botulinum neurotoxin A (BoNT/A) is the most potent toxin known Unfortunately, it is also a potential bioweapon in terrorism, which is without an approved therapeutic treatment once cellular intoxication takes place Previously, we reported how hydroxamic acid prodrug carbamates increased cellular uptake, which translated to successful inhibition of this neurotoxin Building upon this research, we detail BoNT/A protease molecular modeling studies accompanied by the construction of small library of hydroxamic acids based on 2,4-dichlorocinnamic hydroxamic acid scaffold and their carbamate prodrug derivatization along with the evaluation of these molecules in both enzymatic and cellular models