1552290-08-0

Basic information

• Product Name: ethyl 2-(4-bromo-3-trifluoromethylphenyl)acetate
• Synonyms: ethyl 2-(4-bromo-3-trifluoromethylphenyl)acetate
• CAS NO: 1552290-08-0
• Molecular Weight: 311.098
• Mol File: 1552290-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-bromo-3-trifluoromethylphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-bromo-3-trifluoromethylphenyl)acetate(1552290-08-0)
• EPA Substance Registry System: ethyl 2-(4-bromo-3-trifluoromethylphenyl)acetate(1552290-08-0)

Safety Data

• Hazardous Substances Data: 1552290-08-0(Hazardous Substances Data)

Upstream product

• 364-11-4 1-bromo-4-iodo-2-(trifluoromethyl)benzene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 

Relevant articles and documents

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.