1552302-02-9

Basic information

• Product Name: 3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(4-hydroxyphenyl)propanoic acid
• Synonyms: 3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(4-hydroxyphenyl)propanoic acid
• CAS NO: 1552302-02-9
• Molecular Weight: 302.327
• Mol File: 1552302-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(4-hydroxyphenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(4-hydroxyphenyl)propanoic acid(1552302-02-9)
• EPA Substance Registry System: 3-(2-hydroxy-5-(2-hydroxyethyl)phenyl)-3-(4-hydroxyphenyl)propanoic acid(1552302-02-9)

Safety Data

• Hazardous Substances Data: 1552302-02-9(Hazardous Substances Data)

Upstream product

• 7400-08-0 p-Coumaric Acid 
• 1552301-92-4 2-[4-(4-hydroxyphenyl)-2-oxochroman-6-yl]ethyl methyl carbonate 
• 501-94-0 p-hydroxyphenethyl alcohol 
• 953422-33-8 2-(4'-hydroxyphenyl)ethyl methyl carbonate 
• 55226-78-3 methyl (2E)-3-[4-(acetyloxy)phenyl]-2-propenoate 
• 27542-85-4 4-acetoxycinnamic acid 

Relevant articles and documents

Synthesis and DPPH radical scavenging activity of novel compounds obtained from tyrosol and cinnamic acid derivatives

Tyrosol, a naturally occurring phenolic compound poorly attractive as an antioxidant because of its weak efficacy, was used as starting material to obtain novel compounds. The synthesis is based on a trifluoroacetic acid-mediated hydroarylation of cinnamic esters with tyrosol to produce 4-aryl-3,4-dihydrocoumarins, molecules of biological interest, followed by a basic hydrolysis to give the corresponding ring opening products. Unreported mechanistic investigations confirmed that the first step resulted from an electrophilic aromatic substitution and an intramolecular transesterification. Final products exhibited DPPH radical scavenging activity significantly higher than tyrosol.