155335-07-2

Basic information

• Product Name: 2-(prop-1-ynyl)trifluoroacetanilide
• Synonyms: 2-(prop-1-ynyl)trifluoroacetanilide
• CAS NO: 155335-07-2
• Molecular Weight: 227.186
• Mol File: 155335-07-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(prop-1-ynyl)trifluoroacetanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(prop-1-ynyl)trifluoroacetanilide(155335-07-2)
• EPA Substance Registry System: 2-(prop-1-ynyl)trifluoroacetanilide(155335-07-2)

Safety Data

• Hazardous Substances Data: 155335-07-2(Hazardous Substances Data)

Upstream product

• 143321-89-5 2,2,2-trifluoro-N-(2-iodophenyl)acetamide 
• 74-99-7 prop-1-yne 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 5782-14-9 2-methyl-3-(4-methoxybenzene)-1H-indole 
• 26211-90-5 2-methyl-3-(4-methoxybenzoyl)indole 

Relevant articles and documents

Ni-Catalyzed Reductive Coupling of Alkynes and Amides to Access Multi-Functionalized Indoles

A nickel-catalyzed reductive coupling of alkynes and amides, followed by base-free transmetalation, proceeded selectively in the presence of an uncommon bidentate primary aminophosphine ligand to access highly functionalized indoles comprising biologically important trifluoromethyl groups and challenging electron-rich alkenyl groups at the 2-and 3-positions, respectively. Indole molecules were installed within natural products or drug molecules under mild conditions, and a trifluoromethylated analogue of a drug molecule (pravadoline) was also synthesized.