155395-45-2

Basic information

• Product Name: 2-(2-FURYL)BENZONITRILE
• Synonyms: AKOS BAR-0088;2-FURAN-2-YL-BENZONITRILE;2-(2-FURYL)BENZONITRILE
• CAS NO: 155395-45-2
• Molecular Formula: C₁₁H₇NO
• Molecular Weight: 169.18
• Mol File: 155395-45-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 317.3 °C at 760 mmHg
• Flash Point: 145.7 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0.000388mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(2-FURYL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FURYL)BENZONITRILE(155395-45-2)
• EPA Substance Registry System: 2-(2-FURYL)BENZONITRILE(155395-45-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 155395-45-2(Hazardous Substances Data)

Usage

Description

2-(2-FURYL)BENZONITRILE, also known as 2-furan-2-yl-benzonitrile, is an organic compound that has gained attention for its potential applications in various fields. It is characterized by its unique chemical structure, which includes a benzene ring fused with a nitrile group and a furyl group, providing it with distinct properties and reactivity.

Uses

Used in Green Chemistry:
2-(2-FURYL)BENZONITRILE is used as a catalyst in the green arylation of enol acetates and heteroarenes with aryl diazonium salts in water. This application is particularly significant because it promotes environmentally friendly chemical reactions by utilizing water as a solvent and UiO-66 nanocrystals as catalysts, reducing the use of hazardous chemicals and waste generation.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(2-FURYL)BENZONITRILE can be used as a building block or intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
2-(2-FURYL)BENZONITRILE is also used as a research compound in academic and industrial laboratories. Its reactivity and structural features make it a valuable tool for studying various chemical reactions and mechanisms, contributing to the advancement of chemical knowledge and the development of new materials and compounds.

InChI:InChI=1/C11H7NO/c12-8-9-4-1-2-5-10(9)11-6-3-7-13-11/h1-7H

Upstream product

• 110-00-9 furan 
• 394-47-8 2-fluorobenzonitrile 
• 873-32-5 2-Chlorobenzonitrile 
• 81745-86-0 2-furylzinc chloride 
• 55165-45-2 2-cyano-benzenediazonium tetrafluoroborate 
• 2042-37-7 o-cyanobromobenzene 
• 134-20-3 2-carbomethoxyaniline 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 1215172-73-8 2-(furan-2-yl)benzoyl chloride 
• 39732-01-9 2-(2-furyl)benzoic acid methyl ester 
• 331942-47-3 2-(furan-2-yl)benzoic acid 
• 1885-29-6 anthranilic acid nitrile 
• 4387-36-4 2-iodobenzonitrile 

Downstream Products

• 299442-23-2 o-(5-formyl-2-furyl)benzonitrile 

Relevant articles and documents

Carbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds

A highly regioselective, carbazole based Electron Donor Acceptor (EDA) catalyzed synthesis of biaryl and aryl-heteroaryl compounds is described. Various indole and carbazole derivatives were screened for the Homolytic Aromatic Substitution (HAS) reaction. Tetrahydrocarbazole (THC) was very efficient for the HAS transformation and proceeded via a complex formation between diazonium salt and electron rich tetrahydrocarbazole. The UV-Vis spectroscopy technique has been used to confirm the complex formation. The in situ generated EDA complex even in a catalytic amount is found to be efficient for the Single Electron Transfer (SET) process without any photoactivation. Biaryl compounds, 2-phenylfuran, 2-phenylthiophene, and 2-phenylpyrrole and bioactive compounds such as dantrolene and canagliflozin have been synthesized in moderate to excellent yields.

C-H arylation reactions through aniline activation catalysed by a PANI-g-C3N4-TiO2 composite under visible light in aqueous medium

A PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for radical C-H arylation reactions. The arylation process involved coupling of in situ generated aryl diazonium salts from aniline with heteroarenes, enol acetates or benzoquinones under visible light in aqueous medium or pure water. A broad range of substrates survived the reaction conditions to provide the desired products in moderate to good yields. Scale-up (10 mmol) synthesis was also achieved. This semiconductor photocatalyst showed good photocatalytic performance and stability. Recycle studies showed that this composite could be readily recovered and a slight decrease in the catalytic activity was observed after ten consecutive runs.

Simple and Efficient Large-scale Metal-free Synthesis of o-(5-Formyl-2-thienyl)benzonitrile and o-(5-Formyl-2-furyl)benzonitrile

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