155397-18-5

Basic information

• Product Name: 1-Propanol, 1,1-bis(dimethylphenylsilyl)-2-methyl-
• CAS NO: 155397-18-5
• Molecular Formula: C20H30OSi2
• Molecular Weight: 342.629
• Mol File: 155397-18-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Propanol, 1,1-bis(dimethylphenylsilyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanol, 1,1-bis(dimethylphenylsilyl)-2-methyl-(155397-18-5)
• EPA Substance Registry System: 1-Propanol, 1,1-bis(dimethylphenylsilyl)-2-methyl-(155397-18-5)

Safety Data

• Hazardous Substances Data: 155397-18-5(Hazardous Substances Data)

Upstream product

• 547-63-7 Methyl isobutyrate 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 100-61-8 N-methylaniline 
• 55577-65-6 2,N-dimethyl-N-phenylpropanamide 
• 69737-54-8 N,N-diphenyl-2-methylpropanamide 
• 79-30-1 isobutyryl chloride 
• 20279-29-2 phenyl isobutyrate 
• 97-85-8 isobutyl isobutanoate 

Downstream Products

• 155397-24-3 1-[dimethyl(phenyl)vinyl]-2-methylpropan-1-one 
• 65119-04-2 (E)-dimethyl(1-methyl-1-propenyl)phenylsilane 
• 80279-02-3 dimethyl(2-methylprop-1-en-1-yl)(phenyl)silane 
• 116487-96-8 (Z)-dimethyl(1-methyl-1-propenyl)phenylsilane 

Relevant articles and documents

The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides

The reactions of the silyllithium reagent with tertiary amides was discussed. The enediamines were easily isomerized from cis to trans, easily oxidized to dienediamines and were hydrolyzed to α-aminoketones. If the two equivalents of the silyllithium reagent were used, the product was an α-silylamine. The results show that each member of the homologous series of amides gives rise to a substantially different product.

Synthesis of Acylsilanes from Amides and Esters, and the Selective Oxidation of α-Silyl Alcohols to Aldehydes

The acylsilanes 2 can easily be made directly from the dimethylamides 3 by treatment with phenyldimethylsilyllithium.They can also be made in two steps from the esters 4 using 2 equiv. of phenyldimethylsilyllithium followed by oxidation of the disilyl alcohols 5 with PDC.The disilyl alcohols 5 can be used as intermediates in the conversion of esters into aldehydes without recourse to hydride reagents, by monodesilylation, using a Brook rearrangement, followed by oxidation and selective removal of the silyl group, using chromium trioxide in DMSO.