1554456-21-1

Basic information

• Product Name: 1-morpholino-2-(m-tolyl)ethane-1,2-dione
• Synonyms: 1-morpholino-2-(m-tolyl)ethane-1,2-dione
• CAS NO: 1554456-21-1
• Molecular Weight: 233.267
• Mol File: 1554456-21-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-morpholino-2-(m-tolyl)ethane-1,2-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-morpholino-2-(m-tolyl)ethane-1,2-dione(1554456-21-1)
• EPA Substance Registry System: 1-morpholino-2-(m-tolyl)ethane-1,2-dione(1554456-21-1)

Safety Data

• Hazardous Substances Data: 1554456-21-1(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 7023-80-5 2-Diazo-3'-methylacetophenon 
• 95416-60-7 3-(3-methylphenyl)propanal 
• 1875-89-4 2-(3-methylphenyl)ethanol 
• 585-74-0 3-Methylacetophenone 
• 201230-82-2 carbon monoxide 
• 625-95-6 3-Iodotoluene 
• 73318-83-9 2-oxo-2-(m-tolyl)acetaldehyde 

Relevant articles and documents

Preparation method of alpha-carbonyl amide compound

The invention discloses a preparation method of an alpha-carbonyl amide compound. The method comprises the following steps: under the action of a catalyst, taking oxygen as an oxidant, and carrying out oxidative amidation reaction on an alpha-diazoketone compound shown in a chemical formula 2 and a cyclic secondary amine compound shown in a chemical formula 3 in an organic solvent to obtain the alpha-carbonyl amide compound shown in a chemical formula 1, wherein the formulas 1, 2 and 3 are also shown in the speification. According to the preparation method disclosed by the invention, the alpha-carbonyl amide compound is obtained by taking oxygen as the oxidizing agent and catalyzing alpha-diazoketone and cyclic secondary amine to be subjected to oxidative amidation reaction through cuprous iodide, the reaction condition is mild, the reaction time is short, and the byproduct of the reaction is only nitrogen, so that the method is an effective way for green and efficient preparation of the alpha-carbonyl amide compound.

Cu(OAc)2 and acids promoted the oxidative cleavage of α-aminocarbonyl compounds with amines: efficient and selective synthesis of 2-t-amino-2-imino-carbonyl and 2-amino-2-oxocarbonyl

A novel and efficient method for the synthesis of 2-t-amino-2-imino-carbonyl (C) and 2-amino-2-oxocarbonyl (D) compounds has been discovered through a copper-promoted oxidating amidation reactions between α-amino -carbonyl compounds and amines. Promoted by the crucial copper species, perfect selectivity and good to excellent yields could be achieved. This transformation is achieved through C[sbnd]N bond oxidative cleavage and formation a novel C[sbnd]N bond. This reaction system has a broad reaction scope, providing a facile pathway for the α-functionalization of α-amino ketones.

Copper-TEMPO-catalyzed synthesis of α-ketoamides: Via tandem sp3C-H aerobic oxidation and amination of phenethyl alcohol derivatives

An efficient copper-TEMPO-catalyzed one-pot synthesis of α-ketoamides from phenethyl alcohol derivatives was developed firstly. Moreover, molecular oxygen in open air was employed as the oxidant with a broad substrate scope, which makes this methodology more practical. Based on some control experiments, a plausible mechanism was proposed.