15548-52-4 Usage
General Description
Uridine, 5'-(dihydrogen phosphorothioate) is a modified form of the nucleoside uridine that contains a dihydrogen phosphorothioate group at the 5' position. This modification is commonly used in the development of nucleic acid-based therapeutics, such as antisense oligonucleotides, due to its ability to enhance the stability and binding affinity of the oligonucleotides to their target RNA molecules. The dihydrogen phosphorothioate group also imparts nuclease resistance, improving the pharmacokinetic properties of the oligonucleotides. Additionally, this modification has been shown to enhance the cellular uptake of oligonucleotides, leading to increased efficacy in therapeutic applications. Overall, the addition of 5'-(dihydrogen phosphorothioate) to uridine represents an important advancement in the field of nucleic acid-based therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 15548-52-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,4 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 15548-52:
(7*1)+(6*5)+(5*5)+(4*4)+(3*8)+(2*5)+(1*2)=114
114 % 10 = 4
So 15548-52-4 is a valid CAS Registry Number.
15548-52-4Relevant articles and documents
PREPARATION OF DERIVATIVES OF INOSINE 5'-PHOSPHOROTHIOATE FOR USE IN AFFINITY CHROMATOGRAPHY
Kois, Pavol,Holy, Antonin
, p. 2830 - 2838 (2007/10/02)
In the paper the known methods of preparation of ribonucleoside 5'-phosphorothioates II are evaluated and an improved method of their synthesis is described, based on the reaction of 2',3'-O-ethoxymethyleneribonucleosides III with thiophosphoryl chloride in the presence of one equivalent of pyridine, and subsequent hydrolysis.Inosine 5'-phosphate and inosine 5'-phosphorothioate (IIc) were converted to 2',3'-O-cyclic ketals of levulinic acid Vb, VIb on reaction with ethyl levulinate and ethyl orthoformate and subsequent alkaline hydrolysis.O-(4-Aminophenyl)inosine 5'-phosphorothioate (IX) was prepared from 2',3'-O-isopropylideneinosine (VII) with O-(4-nitrophenyl)thiophosphoryldiimidazolide and subsequent catalytic hydrogenation of the O-(4-nitrophenyl) ester VIII formed.
