15548-89-7Relevant articles and documents
Reactivity of hydroxy and amino derivatives of 2-phenyl-1H-imidazoline and 2-phenyl-1H-imidazole toward isocyanates: Synthesis of appropriate carbamates and ureas
Parik, Patrik,Jansa, Josef,Holesova, Sylva,Marek, Ales,Klimesova, Vera
, p. 903 - 910 (2013/08/23)
Reactivity of 2-(4-hydroxyphenyl)-1H-imidazoline and 2-(4-hydroxyphenyl)- 1H-imidazole toward substituted phenyl isocyanates was studied. When mentioned imidazoline was treated with 2.5 equiv of substituted phenyl isocyanate, three N,O-dicarboxamides were
Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives
Sun, Min,Wu, Xiaoqing,Chen, Junqing,Cai, Jin,Cao, Meng,Ji, Min
experimental part, p. 2299 - 2306 (2010/07/05)
Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.