155509-47-0

Basic information

• Product Name: (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester
• CAS NO: 155509-47-0
• Molecular Weight: 455.165
• Mol File: 155509-47-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester(155509-47-0)
• EPA Substance Registry System: (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-aza-bicyclo[3.2.1]octane-2,8-dicarboxylic acid 2-methyl ester 8-(2,2,2-trichloro-ethyl) ester(155509-47-0)

Safety Data

• Hazardous Substances Data: 155509-47-0(Hazardous Substances Data)

Upstream product

• 481-37-8 ecgonine 
• 53-21-4 (-)-cocaine hydrochloride 
• 50373-10-9 methyl ecgonidine 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 130342-80-2 2β-carbomethoxy-3β-(4-chlorophenyl)tropane 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 

Downstream Products

• 281667-94-5 FECNT 
• 1610603-78-5 C₃₂H₃₈Cl₂N₂O₄ 
• 155509-48-1 N-propyn-1-yl-2β-carbomethoxy-3β-(4-chlorophenyl)tropane 
• 251538-84-8 (1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-ethoxycarbonylmethyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester 
• 190326-85-3 (1S,3S,4S,8R)-3-(4-Chloro-phenyl)-7-aza-tricyclo[5.3.0.0^4,8]decan-5-one 
• 146725-33-9 O 374 

Relevant articles and documents

Synthesis of novel halo and tosyloxy nortropane derivatives as efficient precursors for the one-step synthesis of the dopamine transporter PET ligand [18F]FECNT

The fluorine-18 labeled nortropane derivative 2β-carbomethoxy-3β- (4-chlorophenyl)-8-(2-fluoroethyl)-nortropane (FECNT) is a dopamine transporter (DAT) ligand. Currently, it is considered as reference for positron emission tomography imaging. Herein, the synthesis of novel precursors (N-tosyloxy-, chloro-, and bromo- analogues) for one-step radiosynthesis of [ 18F]FECNT is reported. Using the N-mesyloxy- precursor in a one-step radiosynthesis, the crude [18F]FECNT was obtained with the radiolabeling yield of 45 ± 10%, confirming the practical efficiency of this approach in the design of novel precursors for labeling. Copyright

Synthesis, characterization and in vivo evaluation of (N-((E)-4-[18F]fluorobut-2-EN-1-YL)-2β-carbomethoxy-3β-(4-substitute -phenyl)nortropanes for imaging DAT by PET

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