155586-38-2Relevant articles and documents
Gold-based immunochromatographic strip assay for detecting dimethomorph in vegetables
Kuang, Hua,Liu, Liqiang,Xiang, Tongyue,Xu, Chuanlai,Xu, Liguang,Xu, Xinxin
, p. 3882 - 3888 (2022/03/07)
Dimethomorph (DMM) is a novel therapeutic fungicide, which is mainly used to control downy mildew, phytophthora, and other fungal diseases of grapes, leeks, and cucumbers. Its residue is harmful to the human body and the soil environment. In this study, the optimum monoclonal antibody (mAb) against DMM was prepared after routine fusion and selection. Based on the mAb, an indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) and a gold nanoparticle immunochromatographic assay (GNP-ICA) were developed for detecting DMM in leek samples. The 50% inhibitory concentration (IC50) of the mAb was 1.823 ng mL-1, and its cross-reactivity with structurally related analogs was less than 3%. Under optimal conditions, the visible detection limit of this ICA method was 10 ng g-1, and the cutoff value of DMM in leeks was 100 ng g-1. The analysis of DMM in leeks showed that the results of the strip analysis were highly comparable with those of ic-ELISA and liquid chromatography-mass spectrometry LC-MS. Therefore, the GNP immunoassay is a sensitive screening method for detecting DMM residues in foods.
An Efficient synthesis of Weinreb amides and ketones via palladium nanoparticles on ZIF-8 catalysed carbonylative coupling
Thanh Dang, Tuan,Chen, Anqi,Majeed Seayad, Abdul
, p. 30019 - 30027 (2014/08/05)
Heterogeneously catalysed carbonylative coupling reactions such as aminocarbonylation and Suzuki-carbonylation are reported using Pd nanoparticles supported on ZIF-8 for efficient and environmentally attractive synthesis of Weinreb amides and ketones from aryl bromides or iodides. The catalyst is air stable, offers high activity with very low palladium leaching and is recyclable. The presence of a phosphine ligand was required when aryl bromides were used as substrates, while no ligand was necessary when aryl iodides were used. the Partner Organisations 2014.
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
Lee, Ki-Ho,Park, Chun-Eung,Min, Kyung-Hyun,Shin, Yong-Je,Chung, Coo-Min,Kim, Hui-Ho,Yoon, Hae-Jeoung,Won-Kim,Ryu, Eun-Ju,Shin, Yu-Jin,Nam, Hyun-Sik,Cho, Jeong-Woo,Lee, Hee-Yoon
scheme or table, p. 5567 - 5571 (2010/12/29)
A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In