15563-46-9

Basic information

• Product Name: 4-chloro-N,N-dimethylbenzenecarbothioamide
• CAS NO: 15563-46-9
• Molecular Formula: C₉H₁₀ClNS
• Molecular Weight: 199.7004
• Mol File: 15563-46-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 260.6°C at 760 mmHg
• Flash Point: 111.4°C
• Density: 1.213g/cm³
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 4-chloro-N,N-dimethylbenzenecarbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N,N-dimethylbenzenecarbothioamide(15563-46-9)
• EPA Substance Registry System: 4-chloro-N,N-dimethylbenzenecarbothioamide(15563-46-9)

Safety Data

• Hazardous Substances Data: 15563-46-9(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 68-12-2 N,N-dimethyl-formamide 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 20193-94-6 bis-(4-methyl-benzyl)-disulfide 
• 14062-80-7 N,N-dimethyl-4-chlorobenzamide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 1615-02-7 p-chlorocinnamic acid 
• 137-26-8 Thiram 
• 127-19-5 N,N-dimethyl acetamide 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 

Downstream Products

• 95213-62-0 4-Chloro-N'-ethylsulfanyl-N,N-dimethyl-benzamidine 
• 95213-53-9 C₁₁H₁₅ClN₄S 

Relevant articles and documents

Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide

A novel and convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) without the use of sulfurating reagent was explored. In the presence of CuI and di- tert -butyl peroxide (DTBP), various aryl thioamides were prepared with good to excellent yields, tetramethylthiuram disulfide as thioamide source is essential for this transformation. The protocol features broad substrate scope, nice yields, operability and commercially available and inexpensive raw materials, showing its practical synthetic value in organic synthesis.

Metal-free three-component synthesis of thioamides from β-nitrostyrenes, amines and elemental sulfur

A metal-free C[dbnd]C bond cleavage reaction of β-nitrostyrenes in the presence of elemental sulfur and secondary amines/amides is described. Elemental sulfur serves as both a raw material and an oxidant for C[dbnd]C bond cleavage, and secondary amines or amides are both feasible nitrogen sources. Besides mild reaction condition and simple work-up procedure, the method provided thioamides with good to excellent yields.

K2S2O8-promoted aryl thioamides synthesis from aryl aldehydes using thiourea as the sulfur source

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.