155672-58-5Relevant articles and documents
ANTIHISTAMINE SUBSTANCES. TRICYCLIC ANALOGUES OF N-(4,4-DIPHENYL-3-BUTENE-1-YL)NIPECOTIC ACID AND SOME RELATED COMPOUNDS
Sindelar, Karel,Silhankova, Alexandra,Urban, Jiri,Metys, Jan,Valchar, Martin,Polivka, Zdenek
, p. 667 - 674 (1994)
Alkylation of ethyl nipecotate with bromides VII - X gave amino esters Ib - Vb.Alkylation of ethyl piperazine-2-carboxylate with 4-bromo-1,1-diphenyl-1-butene afforded compound Vb.Final products Ia - Va were obtained by acid hydrolysis of corresponding esters Ib - Vb.Some of the compounds showed significant antihistamine and antiulcer activities.