155683-00-4

Basic information

• Product Name: Notoginsenoside Ft1
• Synonyms: Notoginsenoside Ft1;(3beta,12beta,20R)-12,20-Dihydroxydammar-24-en-3-yl O-beta-D-xylopyranosyl-(1- 2)-O-beta-D-glucopyranosyl-(1-2)-beta-D-glucopyranoside
• CAS NO: 155683-00-4
• Molecular Formula: C47H80O17
• Molecular Weight: 917.1279
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 155683-00-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 997.8±65.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• PKA: 12.84±0.70(Predicted)
• CAS DataBase Reference: Notoginsenoside Ft1(CAS DataBase Reference)
• NIST Chemistry Reference: Notoginsenoside Ft1(155683-00-4)
• EPA Substance Registry System: Notoginsenoside Ft1(155683-00-4)

Safety Data

• Hazardous Substances Data: 155683-00-4(Hazardous Substances Data)

Usage

Description

Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities, including promoting angiogenesis, cell proliferation, migration, and tube formation in human umbilical vein endothelial cells (HUVECs). It also induces cell cycle arrest and apoptosis in SH-SY5Y cells, increases cGMP levels, and induces relaxation in rat mesenteric arteries. Furthermore, it has been shown to decrease wound diameter and bleeding time, as well as promote thrombus formation and wound healing in various animal models.

Uses

Used in Pharmaceutical Applications:
Notoginsenoside Ft1 is used as a therapeutic agent for promoting angiogenesis and wound healing due to its ability to induce cell proliferation, migration, and tube formation in HUVECs, as well as its effects on cGMP levels and blood vessel relaxation.
Used in Cardiovascular Applications:
Notoginsenoside Ft1 is used as a vasodilator and anti-platelet agent for the treatment of cardiovascular diseases, as it increases cGMP levels, induces relaxation of isolated precontracted rat mesenteric arteries, and decreases tail bleeding time and increases thrombus weight in a rat tail bleeding assay.
Used in Wound Healing Applications:
Notoginsenoside Ft1 is used as a wound healing agent for the treatment of diabetic foot ulcers and other types of wounds, as it promotes neovascularization, increases mRNA expression of collagen expression and fibroblast proliferation, reduces monocyte infiltration, and shortens wound closure time in a db/db mouse model of diabetic foot ulcers.
Used in Cell Cycle Regulation and Apoptosis:
Notoginsenoside Ft1 is used as a cell cycle regulator and inducer of apoptosis for the treatment of various types of cancer, as it induces cell cycle arrest at the S and G2/M phases and promotes apoptosis of SH-SY5Y cells.