155727-84-7

Basic information

• Product Name: (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one
• Synonyms: (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one
• CAS NO: 155727-84-7
• Molecular Weight: 273.332
• Mol File: 155727-84-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one(155727-84-7)
• EPA Substance Registry System: (4S)-4-isobutyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one(155727-84-7)

Safety Data

• Hazardous Substances Data: 155727-84-7(Hazardous Substances Data)

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 17016-85-2 (S)-(-)-4-isobutyloxazolidin-2-one 
• 104-55-2 3-phenyl-propenal 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 1020737-91-0 C₁₆H₂₁NO₅ 
• 1020737-89-6 C₁₆H₂₁NO₅ 
• 86117-68-2 dimethyl (3R,4R)-diphenyladipate 
• 61883-07-6 meso-3,4-diphenyl-adipic acid dimethyl ester 
• 147599-28-8 4-((2R,3R)-5-oxo-3-phenyltetrahydrofuran-2-yl)benzonitrile 

Relevant articles and documents

N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis

The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.