1558054-04-8

Basic information

• Product Name: (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one
• Synonyms: (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one
• CAS NO: 1558054-04-8
• Molecular Weight: 494.955
• Mol File: 1558054-04-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(1558054-04-8)
• EPA Substance Registry System: (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-propan-1-one(1558054-04-8)

Safety Data

• Hazardous Substances Data: 1558054-04-8(Hazardous Substances Data)

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 4106-18-7 1-(phenylsulfonyl)-1H-benzo[d][1,2,3]triazole 
• 80360-21-0 1-(benzenesulfonyl)-2-methyl-1H-indole 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 172877-90-6 1-[2-(bromomethyl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 

Downstream Products

• 1597408-97-3 3-chloro-12-(phenylsulfonyl)-12H-indolo[3,2-j]phenanthridin-7-ol 
• 1445974-01-5 2-(4-chloro-2-nitrophenyl)-4-hydroxy-9-(phenylsulfonyl)-9H-carbazole-3-carbaldehyde 
• 1597408-91-7 2-(4-chloro-2-nitrophenyl)-4-methoxy-9-(phenylsulfonyl)-9H-carbazole-3-carbaldehyde 
• 1597408-86-0 3-(bromomethyl)-2-(4-chloro-2-nitrophenyl)-4-methoxy-9-(phenylsulfonyl)-9H-carbazole 
• 1597408-80-4 2-(4-chloro-2-nitrophenyl)-4-methoxy-3-methyl-9-(phenylsulfonyl)-9H-carbazole 
• 1597408-62-2 (E)-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]-2-(phenylsulfonyl)propan-1-one 
• 1597408-54-2 (E)-2-bromo-1-[2-(4-chloro-2-nitrostyryl)-1-(phenylsulfonyl)-1H-indol-3-yl]propan-1-one 

Relevant articles and documents

Total synthesis of calothrixin B and its analogs

The total synthesis of calothrixin B and its analogs was achieved starting from 2-methylindole. The synthesis involved an electrocyclization of 2-nitroarylvinyl-3-phenylsulfonylvinylindoles as a key step to give 2-nitroaryl-4-methoxy-3-methylcarbazoles. Oxidation of these compounds followed by reductive cyclization led to N-phenylsulfonylquinocarbazoles. These quinocarbazoles underwent hydrolysis and aerial oxidation in one pot to give the target compounds. A linear synthesis of calothrixin B and its analogs has been established from commercially available 2-methylindole. The thermal electrocyclization of 2-nitroarylvinyl-3-phenylsulfonylindole was a key step in the synthesis. The synthesis of calothrixin B and its analogs was achieved in 12-22 % overall yield over twelve steps. Copyright