155825-57-3Relevant articles and documents
Enantioselective hydrogenation of β-ketoesters with monodentate ligands
Junge, Kathrin,Hagemann, Bernhard,Enthaler, Stephan,Oehme, Guenther,Michalik, Manfred,Monsees, Axel,Riermeier, Thomas,Dingerdissen, Uwe,Beller, Matthias
, p. 5066 - 5069 (2004)
Efficient and stable chiral monodentate phosphine ligands can be used in the ruthenium-catalyzed enantioselective hydrogenation of β-ketoesters (see scheme). The catalysts are remarkably temperature-tolerant, and enantioselectivities of up to 95% ee are possible, even at 100-120 °C. R = C6H5, p-CH3OC6H4, p-CF3OC6H4, iPr, Et, C6D 5.
A Mild One-Pot Reduction of Phosphine(V) Oxides Affording Phosphines(III) and Their Metal Catalysts
Kapu?niak, ?ukasz,Plessow, Philipp N.,Trzybiński, Damian,Wo?niak, Krzysztof,Hofmann, Peter,Jolly, Phillip Iain
supporting information, p. 693 - 701 (2021/04/06)
The metal-free reduction of a range of phosphine(V) oxides employing oxalyl chloride as an activating agent and hexachlorodisilane as reducing reagent has been achieved under mild reaction conditions. The method was successfully applied to the reduction of industrial waste byproduct triphenylphosphine(V) oxide, closing the phosphorus cycle to cleanly regenerate triphenylphosphine(III). Mechanistic studies and quantum chemical calculations support the attack of the dissociated chloride anion of intermediated phosphonium salt at the silicon of the disilane as the rate-limiting step for deprotection. The exquisite purity of the resultant phosphine(III) ligands after the simple removal of volatiles under reduced pressure circumvents laborious purification prior to metalation and has permitted the facile formation of important transition metal catalysts.
