155852-41-8

Basic information

• Product Name: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester
• Synonyms: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester;Methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate;2-(2,3-Dihydrobenzofuran-5-yl)acetic Acid Methyl Ester;Methyl 2,3-dihydro-1-benzofuran-5-ylacetate
• CAS NO: 155852-41-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.21118
• Product Categories: Aromatics;Heterocycles
• Mol File: 155852-41-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 287.8°C at 760 mmHg
• Flash Point: 116.1°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0.00243mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Dichloromethane, Ethyl Acetate, Methanol (Slightly)
• CAS DataBase Reference: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester(155852-41-8)
• EPA Substance Registry System: 2,3-Dihydro-5-benzofuranacetic Acid Methyl Ester(155852-41-8)

Safety Data

• Hazardous Substances Data: 155852-41-8(Hazardous Substances Data)

Usage

Description

2,3-Dihydro-5-benzofuranacetic acid methyl ester, with the CAS number 155852-41-8, is an organic compound that is characterized by its brown oil appearance. It is a derivative of benzofuranacetic acid, featuring a methyl ester functional group. 2,3-Dihydro-5-benzofuranacetic acid methyl ester is known for its utility in various organic synthesis processes, making it a valuable component in the field of chemistry.

Uses

Used in Organic Synthesis:
2,3-Dihydro-5-benzofuranacetic acid methyl ester is used as a synthetic intermediate for the creation of various complex organic molecules. Its unique structure allows it to serve as a building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,3-Dihydro-5-benzofuranacetic acid methyl ester is used as a key component in the development of new drugs. Its chemical properties make it suitable for the synthesis of novel therapeutic agents, potentially leading to the discovery of innovative treatments for various diseases and medical conditions.
Used in Agrochemical Industry:
2,3-Dihydro-5-benzofuranacetic acid methyl ester also finds application in the agrochemical industry, where it is utilized in the synthesis of new pesticides, herbicides, and other crop protection agents. Its incorporation into these products can contribute to the development of more effective and environmentally friendly solutions for agricultural challenges.
Used in Specialty Chemicals:
2,3-Dihydro-5-benzofuranacetic acid methyl ester is also used in the production of specialty chemicals, which are tailored to meet the specific requirements of various industries. The versatility of 2,3-Dihydro-5-benzofuranacetic acid methyl ester makes it a valuable asset in the development of customized chemical products for applications such as coatings, adhesives, and polymers.

InChI:InChI=1/C11H12O3/c1-13-11(12)7-8-2-3-10-9(6-8)4-5-14-10/h2-3,6H,4-5,7H2,1H3

Upstream product

• 67-56-1 methanol 
• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 
• 156-38-7 4-hydroxyphenylacetate 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 

Downstream Products

• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 
• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 

Relevant articles and documents

Iridium-Catalyzed Amidation of in Situ Prepared Silyl Ketene Acetals to Access α-Amino Esters

Disclosed herein is a convenient Ir-catalyzed amidation of esters to access α-amido esters. Initially prepared silyl ketene acetals are directly employed, without separate purification, for subsequent amidation with an oxycarbonylnitrenoid precursor using the Cp*(LX)Ir(III) catalyst. The α-amidation was facile for both α-aryl and α-alkyl esters. Density functional theory studies revealed that the generation of a putative Ir-nitrenoid is facilitated by the chelation of the countercation additive during the N-O bond cleavage of the nitrene precursor.

Darifenacin intermediate 2, 3 - dihydro - 5 - benzofuran acetic acid preparation new method of (by machine translation)

The invention relates to a darifenacin intermediate - 2, 3 - dihydro - 5 - benzofuran acetic acid. By the P-hydroxy-acetic acid and bromo acetaldehyde acetal as the starting material, the presence of O - alkylation reaction under a condition of the corresponding ether compound; then by esterification reaction to obtain the corresponding ester; in PPA (poly phosphoric acid) under the action of the, cyclization to obtain 2, 3 - benzofuran - 5 - acetate; 2, 3 - benzofuran - 5 - acetic acid layer which hydrolysis, to acidify the corresponding carboxylic acid; obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid; or the first 2, 3 - benzofuran - 5 - acetate obtained by catalytic hydrogenation of 2, 3 - dihydro - 5 - benzofuran acetic acid esters; and hydrolyzed, acidified to obtain 2, 3 - dihydro - 5 - benzofuran acetic acid. The method of the invention by simple and safe, each reaction raw materials are cheap and easy to obtain, the reaction yield is high, and is particularly suitable for industrial production of 2, 3 - dihydro - 5 - benzofuran acetic acid. (by machine translation)

Benzoheterocycle derivative having [beta]2 agonist activity, preparation method, and application thereof

The invention relates to a benzoheterocycle derivative having [beta]2 agonist activity, a preparation method, and an application thereof, and in particularly, relates to a compound represented as the general formula (I), or a stereoisomer, a hydrate, a me