15592-29-7

Basic information

• Product Name: 2,2-dimethylpropyl isocyanate
• Synonyms: 2,2-dimethylpropyl isocyanate;Einecs 239-660-1
• CAS NO: 15592-29-7
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.15764
• EINECS: 239-660-1
• Mol File: 15592-29-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 123.9°C at 760 mmHg
• Flash Point: 28.3°C
• Appearance: /
• Density: 0.84g/cm³
• Vapor Pressure: 13mmHg at 25°C
• Refractive Index: 1.424
• CAS DataBase Reference: 2,2-dimethylpropyl isocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethylpropyl isocyanate(15592-29-7)
• EPA Substance Registry System: 2,2-dimethylpropyl isocyanate(15592-29-7)

Safety Data

• Hazardous Substances Data: 15592-29-7(Hazardous Substances Data)

Usage

General Description

2,2-dimethylpropyl isocyanate, also known as isophorone diisocyanate (IPDI), is a chemical compound used in the production of polyurethane coatings, adhesives, and sealants. It is a colorless to pale yellow liquid with a pungent odor and is highly reactive with moisture. IPDI is classified as a hazardous substance and requires careful handling and storage due to its potential to cause skin and respiratory irritation, as well as sensitization and asthma in some individuals. It is important to use proper protective equipment and adhere to safety protocols when working with IPDI to minimize the risk of exposure and ensure safe handling.

InChI:InChI=1/C6H11NO/c1-6(2,3)4-7-5-8/h4H2,1-3H3

Upstream product

• 66661-89-0 3-(2,2-Dimethyl-propyl)-1,1,2-trimethyl-isothiourea 
• 4461-33-0 benzoyl isocyanate 
• 75-44-5 phosgene 
• 15925-18-5 neopentylamine hydrochloride 
• 5813-64-9 2.2-dimethylpropylamine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1070-83-3 tert-Butylacetic acid 
• 25343-65-1 1-isothiocyanato-2,2-dimethylpropane 
• 79505-47-8 neopentyl-carbamic acid phenyl ester 

Downstream Products

• 34207-82-4 C₁₆H₂₃N₃O₄ 
• 34207-54-0 C₁₈H₂₇N₃O₄ 
• 34207-22-2 C₁₈H₂₇N₃O₄ 

Relevant articles and documents

Novel partial agonists for the histamine H3 receptor with high in vitro and in vivo activity

Novel branched N-alkylcarbamates and aliphatic ethers derived from 3- (1H-imidazol-4-yl)-propanol were prepared. The compounds were investigated on two functional histamine H3-receptor assays. Some compounds displayed partial agonist activity on synaptosomes of rat brain cortex but behaved as pure competitive antagonists on the guinea pig ileum. Under in vivo conditions after po application to mice, some of the compounds showed partial or full agonist activity. Highest in vivo potency was found for the 3,3- dimethylbutyl ether 10 (ED50 = 0.29 mg/kg, full intrinsic activity). These novel agonists are structurally diverse from classical aminergic histamine H3-receptor agonists (e.g., (R)-α-methylhistamine, imetit) as they lack a basic moiety in the side chain, which is supposed to be important for the activation of the receptor protein. The selectivity for the histamine H3 receptor was proven by determination of H1- and H2-receptor activity on functional assays of the guinea pig.

N-Substituted imido-dicarboxylic acid diaryl ester compounds and herbicide intermediates

Novel N-substituted imido-dicarboxylic acid diaryl ester compounds of the general formula STR1 in which R1 represents an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic, heterocyclic radical and R2 and R3 can be identical or different and represent an optionally substituted aryl radical, and a process for their preparation characterized in that a carbamic acid aryl ester of the general formula in which R1 and R2 have the abovementioned meanings, is reacted with a carbonic acid aryl ester halide of the general formula in which R3 has the abovementioned meaning and X represents a halogen atom, optionally in the presence of a diluent, optionally at a temperature between 100° and 300° C. The new compounds (I) can be used as intermediate products for the preparation of known herbicidal active compounds from the 1,3,5-triazine,2,4-(1H,3H)-dione series.