156017-45-7Relevant articles and documents
Efficient scaled-up synthesis of Nα-Fmoc-4-phosphono(difluoromethyl)- L-phenylalanine and its incorporation into peptides
Meyer, Christoph,Koehn, Maja
experimental part, p. 3255 - 3260 (2011/11/30)
A rapid, robust and efficient scaled-up synthetic strategy for N - Fmoc-4-phosphono(difluoromethyl)-l-phenylalanine and its direct incorporation into peptides is presented herein. Georg Thieme Verlag Stuttgart · New York.
A facile solution and solid phase synthesis of phosphotyrosine mimetic L-4-[diethylphosphono(difluoromethyl)]-phenylalanine (F2Pmp(EtO)2) derivatives
Qabar, Maher N.,Urban, Jan,Kahn, Michael
, p. 11171 - 11178 (2007/10/03)
The F2Pmp derivatives were prepared in 80-90% yield from commercially available protected L-4-iodophenylalanine by esterification with diazomethane followed by a CuCl-mediated coupling to (diethylphosphonyl) difluoromethylcadmium bromide. Moreover, treatment of L-4-iodoPhe-containing peptides under the same coupling conditions provided the F2Pmp-containing peptides in very good yields.
Enantioselective synthesis of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-l-phenylalanine(F2Pmp)
Smyth, Mark S.,Burke Jr., Terrence R.
, p. 77 - 81 (2007/10/03)
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