156022-78-5Relevant articles and documents
Asymmetric synthesis. XXXI. Synthesis of 2-substituted piperazines from chiral non-racemic lactams
Schanen, Vincent,Riche, Claude,Chiaroni, Angele,Quirion, Jean-Charles,Husson, Henri-Philippe
, p. 2533 - 2536 (1994)
The preparation of lactam 2 from R-(-)-phenylglycinol and N-Boc glycine is described. Diastereoselective alkylation of 2 allowed the preparation of piperazine derivatives in an optically pure form.