156176-93-1

Basic information

• Product Name: 1,8(2H,5H)-Acridinedione, 3,4,6,7,9,10-hexahydro-9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-
• CAS NO: 156176-93-1
• Molecular Formula: C23H27NO3
• Molecular Weight: 365.472
• Mol File: 156176-93-1.mol
• Article Data: 37

Chemical Properties

• CAS DataBase Reference: 1,8(2H,5H)-Acridinedione, 3,4,6,7,9,10-hexahydro-9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8(2H,5H)-Acridinedione, 3,4,6,7,9,10-hexahydro-9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-(156176-93-1)
• EPA Substance Registry System: 1,8(2H,5H)-Acridinedione, 3,4,6,7,9,10-hexahydro-9-(4-hydroxyphenyl)-3,3,6,6-tetramethyl-(156176-93-1)

Safety Data

• Hazardous Substances Data: 156176-93-1(Hazardous Substances Data)

Upstream product

• 329736-70-1 (4-hydroxybenzylidene)bis(dimedone) 
• 126-81-8 dimedone 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 5173-27-3 1,2-bis(4-hydroxyphenyl)-ethane-1,2-diol 
• 123-08-0 4-hydroxy-benzaldehyde 
• 873-95-0 1-amino-5,5-dimethylcyclohexen-3-one 

Downstream Products

• 27361-25-7 3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione 

Relevant articles and documents

Thiosemicarbazide binds with the dicopper center in the competitive inhibition of mushroom tyrosinase enzyme: Synthesis and molecular modeling of theophylline analogues

Theophylline is long known for its anti-ageing and anti-oxidative properties. Moreover, Tyrosinase is a crucial enzyme that regulates the melanin synthetic pathway, which is involved in various physiological metabolic processes including aging. The current paper describes the synthesis of various heterocyclic systems coupled with theophylline moiety along with their tyrosinase inhibition activity in view to identify the potent nucleus. Around 19 compounds were synthesized and screened for enzyme inhibition. Based on the current study, it is suggested that compound 18 having thiosemicarbazide has strong enzyme inhibition potential. The enzyme kinetics and docking studies provide important insights into how the compound interacts with the mushroom tyrosinase active site. The work will provide clue to developing new, potent tyrosinase inhibitors for drug development.

Ag/CuO/MCM-48 As a potential catalyst for the synthesis of symmetrical and unsymmetrical polyhydroquinolines

Ag/CuO/MCM-48 as a heterogeneous catalyst was efficiently employed in the synthesis of diversely substituted symmetrical and unsymmetrical polyhydroquinoline by a multi-component reaction of arylaldehyde, dimedone, ethyl cyanoacetate and ammonium acetate. This novel method is simple, environmentally friendly, rapid, uses a recyclable catalyst and produces the products in high to excellent yields (83-97%) and lower reaction times (17-35 min). The catalyst can be reused at least 10 times without any appreciable decrease in its catalytic activities.

Eco-friendly, ultrasound-assisted, and facile synthesis of one-pot multicomponent reaction of acridine-1,8(2H,5H)-diones in an aqueous solvent

A one-pot, multistep synthesis of acridine-1,8(2H,5H)-diones (4a–m) was achieved by three-component reaction of dimedone (1) with an aromatic aldehyde (2a–m) and an ammonium acetate (3) using water as a green solvent without any catalyst and a simple, eas