156223-05-1 Usage
Description
3-(2,4-dimethoxybenzylidene)anabaseine, also known as GTS-21, is a synthetic compound with a complex chemical structure. It is characterized by its ability to modulate certain receptors in the body, which has led to its exploration for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
3-(2,4-dimethoxybenzylidene)anabaseine is used as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist for its anti-inflammatory effects in mouse macrophages. This application is significant as it may help in the development of new treatments for inflammatory diseases.
Used in Nephrology Research:
In the field of nephrology, 3-(2,4-dimethoxybenzylidene)anabaseine is used to test its protective effect on renal injury induced by lipopolysaccharide (LPS). This is important for understanding its potential role in preventing or treating kidney damage caused by various inflammatory conditions.
Used in Microvascular Inflammation Studies:
3-(2,4-dimethoxybenzylidene)anabaseine is also used to test its effect on microvascular inflammation, which is a common issue in various diseases, including diabetes and atherosclerosis. This application may lead to the development of new therapies for these conditions.
Used in Endotoxemia Research:
Lastly, 3-(2,4-dimethoxybenzylidene)anabaseine is used in endotoxemia induced by LPS to study its potential effects on this severe inflammatory response. Understanding its role in this context could be crucial for developing treatments for sepsis and other related conditions.
Biochem/physiol Actions
GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.
Check Digit Verification of cas no
The CAS Registry Mumber 156223-05-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,2,2 and 3 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 156223-05:
(8*1)+(7*5)+(6*6)+(5*2)+(4*2)+(3*3)+(2*0)+(1*5)=111
111 % 10 = 1
So 156223-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;
