1562416-38-9

Basic information

• Product Name: C₂₁H₁₉NO₃
• CAS NO: 1562416-38-9
• Molecular Weight: 333.387
• Mol File: 1562416-38-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₉NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₉NO₃(1562416-38-9)
• EPA Substance Registry System: C₂₁H₁₉NO₃(1562416-38-9)

Safety Data

• Hazardous Substances Data: 1562416-38-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 149832-10-0 4-(1-naphthalenylmethyl)-2-phenyloxazol-5(4H)-one 
• 55516-54-6 L-1-naphthylalanine 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Peptide-catalyzed conversion of racemic oxazol-5(4 H)-ones into enantiomerically enriched α-amino acid derivatives

We report the development and optimization of a tetrapeptide that catalyzes the methanolytic dynamic kinetic resolution of oxazol-5(4H)-ones (azlactones) with high levels of enantioinduction. Oxazolones possessing benzylic-type substituents were found to perform better than others, providing methyl ester products in 88:12 to 98:2 er. The mechanism of this peptide-catalyzed process was investigated through truncation studies and competition experiments. High-field NOESY analysis was performed to elucidate the solution-phase structure of the peptide, and we present a plausible model for catalysis.